The purpose of this study is to determine whether acetaminophen is effective in prevention or reducing the severity of IVH in premature infants.

It will be a double-blind randomized control trial, single center. The study will include neonates with a gestational age of less than or equal 32 weeks and a birth weight of less than or equal 1500 g, and will randomly assigned to two treatment groups (see below).

Infants will be randomized to equal-sized groups using block randomization with blocks of four. Stratified randomization for gender and gestational age will be included in the randomized blocks. Gestational age will be divided into two categories: 23 weeks +0 day to 27 weeks +6 days, and from 28 weeks +0 day to 32 weeks +6 days. Gender (2) × gestational age (2) will give 6 strata, requiring 6 separate random number lists to achieve randomization.

Inclusion Criteria:

• Premature baby less than or equal 32 week and birth weight less than or equal 1500 g

Exclusion Criteria:

• Out-born babies, infants with major congenital anomalies, babies have IVH III, IV, High expectancy of early death