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To perform a randomized, double-blind clinical study on the effects of an increased salt intake on metabolic, cardiovascular and immunological parameters and the gut microbiota
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Salt | Active Comparator | 6 grams sodium chloride per day for 14 days |
|
| Placebo | Placebo Comparator | 6 grams gelatine per day for 14 days |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Salt | Dietary Supplement | 10 capsules daily for 14 days |
| |
| Placebo |
| Measure | Description | Time Frame |
|---|---|---|
| Dietary induced thermogenis (%) | Decrease of dietary induced thermogenis after salt vs. placebo | 14 days |
| Measure | Description | Time Frame |
|---|---|---|
| Systolic blood pressure (mmHg) | Increase of systolic blood pressure after salt vs. placebo | 14 days |
| Lymphocytic pro-inflammatory mediators | Increase of lymphocytic pro-inflammatory mediators after salt vs. placebo |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Experimental and Clinical Research Center | Berlin | 13125 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35057434 | Result | Mahler A, Klamer S, Maifeld A, Bartolomaeus H, Marko L, Chen CY, Forslund SK, Boschmann M, Muller DN, Wilck N. Increased Salt Intake Decreases Diet-Induced Thermogenesis in Healthy Volunteers: A Randomized Placebo-Controlled Study. Nutrients. 2022 Jan 7;14(2):253. doi: 10.3390/nu14020253. |
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| ID | Term |
|---|---|
| D012492 | Salts |
| ID | Term |
|---|---|
| D007287 | Inorganic Chemicals |
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| Dietary Supplement |
10 capsules daily for 14 days |
|
| 14 days |
| Gut microbiome | Change of gut microbiome composition after salt vs. placebo | 14 days |