To evaluate the safety and tolerability of Hepalatide(L47) and characterize the clinical pharmacokinetics in healthy volunteers.

This is a randomized, double-blinded, dose escalating, phase Ib trial, which will be conducted in No. 302 Hospital of China. There are three cohorts at dose of 4.2mg, 6.3mg and 8.4mg. All healthy volunteers will be randomized into Hepalatide or placebo group at 4:1 rate, all healthy volunteers will be received treatment drug by abdominal subcutaneous injection once a day for seven days and will be observed for 3 days.

Inclusion Criteria:

• Ages between 18 and 45 years
• BMI Index between 19 and 25 (BMI=weight/height2)
• Normal previous history and physical exam
• No drug and alcohol abuse
• No illness in 4 weeks and no drug therapy in 2 weeks
• No blood donation or subject not sampled in 3 months
• Consistent and correct use of recommended methods of birth control for men and women
• Good compliance with study protocol
• Understand and agree to sign a consent form

Exclusion Criteria:

• Infection with HAV, HBV, HCV, HEV, HIV, EBV or CMV
• Abnormal and clinical significance test of physical examination, vital signs, blood routines, urine routines, liver and kidney functions, coagulation indicator, electrolyte, glucose, blood lipid, thyroid functions, chest X-Ray, ECG, B ultrasound of gallbladder, spleen and kidney, AFP ,and CEA
• Positive for anti-Pre-S1 antibody
• Women being pregnant or nursing, or with abnormal sex hormones, B ultrasound of ovaries/uterus proliferative diseases or breast mass
• Unable to quit smoking in trial
• Subject with little chance of enrollment (i.e. the weak)
• Subject not suitable to join the trial under other circumstances judged by investigator.