The Effects of Caffeine Withdrawal on Migraine

The Effects of Caffeine Withdrawal on Migraine - a Randomized, Double-blind, Crossover Study

Sporadic and chronic dietary consumption of caffeine has substantial biological effects on the nervous system. The effects on migraine are at large not known. In this study we want to assess the effects of caffeine withdrawal on migraine.

The actions of caffeine as an antagonist of adenosine receptors have been extensively studied, and there is no doubt that both daily and sporadic dietary consumption of caffeine has substantial biological effects on the nervous system. The current opinion is that caffeine both can cure and trigger headaches. Caffeine is a component of many combination drugs marketed for the relief of headaches, but on the other hand it is strongly incriminated as a risk factor for developing chronic headache. Withdrawal may cause symptom constellations similar to the migraine syndrome. Further, caffeine consumption may affect sleep and alertness, possibly influencing the risk of migraine attacks. .

Inclusion Criteria:

• migraine present for at least 1 year and fulfilling diagnostic criteria (ICHD-3 beta)
• =/> 3 migraine attacks per month
• no migraine prophylaxis the last month
• consumption =/> 300 mg and </= 800 mg caffeine per day the last month
• signed consent

Exclusion Criteria:

• suspicion of medication-overuse headache
• pregnancy and breast feeding
• serious co-morbidity or conditions requiring Medical treatment or caution
• working night shift
• use of drugs with moderate or major interactions with caffeine