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The purpose of this study is to evaluate the Pharmacokinetics and safety of Ravidasvir in Combination with Ritonavir-boosted Danoprevir in Single and Multiple doses in Healthy Participants
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| PKGroup(Ravidasvir/Danoprevir/Ritonavir) | Experimental | Ravidasvir + Danoprevir/ Ritonavir |
|
| Placebo Group | Placebo Comparator | Placebo |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ravidasvir | Drug | Ravidasvir tablet administered orally 200mg QD on day 1, 13 - 23 |
|
| Measure | Description | Time Frame |
|---|---|---|
| Safety: Incidence of adverse events | 40 days |
| Measure | Description | Time Frame |
|---|---|---|
| Pharmacokinetics: Maximum plasma concentration at steady-state (Css,max) | Up to 24 weeks | |
| Pharmacokinetics: Total area under the concentration-time curve form time 0 to 12 hours post-dose at steady-state | Up to 24 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Huoling Tang, PhD | Ascletis Pharmaceuticals Co., Ltd. | Study Director |
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| ID | Term |
|---|---|
| C000621711 | ravidasvir |
| C553752 | danoprevir |
| D019438 | Ritonavir |
| ID | Term |
|---|---|
| D013844 | Thiazoles |
| D013457 | Sulfur Compounds |
| D009930 | Organic Chemicals |
| D001393 | Azoles |
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| Danoprevir | Drug | Danoprevir tablet administered orally 100mg QD on day 7 and 13, 100mg BID on day 14-22, 100mg QD on day 23 |
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| Ritonavir | Drug | Ritonavir tablet administered orally 100mg QD on day 7 and 13, 100mg BID on day 14-22, 100mg QD on day 23 |
|
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| Placebo | Drug | Placebo |
|
| D006573 |
| Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |