Oxycodone vs. Fentanyl in Early Postoperative Pain After Total Hip Replacement

Oxycodone vs. Fentanyl in the Treatment of Early Postoperative Pain After Total Hip Replacement

Oxycodone is one of the most widely used opioids for pain treatment. Many studies demonstrated good efficacy of oxycodone on postoperative pain. In this study, we assess the efficacy and side effects of bolus intravenous of oxycodone injection compared to those of fentanyl in patients after total hip replacement surgery.

Oxycodone is one of the most widely used opioids for pain treatment. There have been several studies on the efficacy and side effects of oxycodone. Oxycodone has been known to have the same potency with morphine. Many studies demonstrated good efficacy of oxycodone on postoperative pain. In this study, we designed a prospective, randomized, and double-blind study to assess the efficacy and side effects of bolus intravenous of oxycodone injection compared to those of fentanyl in patients who underwent the total hip replacement surgery.

Inclusion Criteria:

• 19-65 years of age
• ASA physical status classification I or II
• Scheduled for total hip replacement surgery

Exclusion Criteria:

• Allergic to study drugs
• Patient with asthma or COPD, patient who is severely respiratory depressed
• Renal of hepatic insufficiency
• Epileptic status
• Intracranial lesion associated with increased intracranial pressure
• Acute abdomen, patient who has diagnosed paralytic ileus or suspicious ileus
• Pregnant or lactating women