Menopause is usually associated with an increase in body weight, a change in body composition and fat distribution and a large number of cardio-metabolic changes, such as hypertension, reduction of insulin-sensitivity and dyslipidaemia. The first-line strategy for these complications is the modification of dietary habits and lifestyle in terms of physical activity. Besides, there is also a growing interest in complementary therapies (i.e. nutraceuticals) that can be used alone or in combination to achieve more consistent results. In this context, preliminary evidence supports the potential role of some compounds of vegetal origin such as berberine, chlorogenic acid and tocotrienols. However, in support of their use, the evidence from good quality trials is limited.

Inclusion Criteria:

• LDL cholesterol >100 mg/dL
• Written informed consent available

Exclusion Criteria:

• Use of any drug affecting blood lipids
• Hormone replacement therapy
• Adherence to a weigh loss diet in the previous 6 months
• Cancer diagnosis
• Known thyroid, liver, renal or muscle diseases
• Any medical or surgical condition which could lead to an inconstant adhesion to the protocol