The Study of Two Different Chinese Traditional Medicine Treatment on Chronic Hepatitis B

Efficacy Comparison Between Two Kind of Chinese Herbal Formulas on Traditional Chinese Medicine Syndromes Among Chronic Hepatitis Patients

Although the incidence of Hepatitis B has been decreased a lot recently years, there are still quite a few chronic hepatitis B patients in China. The anti-virus drugs of western medicine such as Entecavir and Tenofovir have been proved effective on decreasing the serum hepatitis B virus (HBV) level, on the other hand, Chinese materia medica showed effective on TCM syndromes of chronic hepatitis B (CHB) such as hypochondriac pain, jaundice and abdominal mass. Besides, the hepatic fibrosis could be delayed after the appropriate treatment of TCM. This study is a multicenter, randomized, open label, parallel group clinical trial to evaluate the efficacy of two different traditional Chinese medicine (TCM) herbal treatment on chronic hepatitis B.

Inclusion Criteria:

• 18<=age at treatment<=65 years old
• Was diagnosed as chronic hepatitis B (ICD10:K73.901) and one of the following Chinese syndromes: hypochondriac pain (TCD:BNG010), jaundice(TCD:BNG020) or abdominal mass (TCD:BNG040).

Exclusion Criteria:

• Combined with other virus hepatitis or alcoholic hepatitis
• Combined with autoimmune disease
• Combined with liver cancer or cirrhosis
• Combined with severe hepatitis with or without complications
• Combined with unstable cardio-cerebrovascular disease
• Combined with severe lung, kidney, endocrine system, nervous system and hematological system diseases
• Combined with Tuberculosis
• Chronic hepatitis patients with ongoing INF treatment
• Woman with pregnancy or breasting feeding
• Mental disorder and can not express self clearly
• Cannot speak Chinese
• Allergic constitution or allergy to multiple drugs
• Refuse to enroll into the study