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The importance of Aldosterone for endothelial function and Insulin resistance observed within patients with type 2 diabetes
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Type 2 Diabetes | Experimental | 8 weeks of treatment with Aldosterone blocker Eplerenone |
|
| Healthy | Experimental | 8 weeks of treatment with Aldosterone blocker Eplerenone |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Eplerenone | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Vascular function | Femoral arterial blood flow in response to femoral arterially infused ACh | 8 weeks |
| Insulin sensitivity measured by a insulin clamp | Glucose infusion rate during euglycaemic-hyperinsulinaemic clamp | 8 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Vascular function | Microperfusion performed on blood vessels in vitro obtained from muscle biopsies | 8 weeks |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Stefan P Mortensen, DMSc | University of Southern Denmark | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cardiovascular and Renal Research | Odense | 5000 | Denmark |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34350730 | Derived | Finsen SH, Hansen MR, Hoffmann-Petersen J, Hojgaard HF, Mortensen SP. Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes. Physiol Rep. 2021 Aug;9(15):e14971. doi: 10.14814/phy2.14971. | |
| 33247722 | Derived | Finsen SH, Hansen MR, Hansen PBL, Mortensen SP. Aldosterone Induces Vasoconstriction in Individuals with Type 2 Diabetes: Effect of Acute Antioxidant Administration. J Clin Endocrinol Metab. 2021 Mar 8;106(3):e1262-e1270. doi: 10.1210/clinem/dgaa867. |
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| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D003924 | Diabetes Mellitus, Type 2 |
| ID | Term |
|---|---|
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
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| ID | Term |
|---|---|
| D000077545 | Eplerenone |
| ID | Term |
|---|---|
| D007783 | Lactones |
| D009930 | Organic Chemicals |
| D011283 | Pregnenes |
| D011278 | Pregnanes |
| D013256 |
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| D003920 | Diabetes Mellitus |
| D004700 | Endocrine System Diseases |
| Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |