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The results of PET/MRI and PET/CT in each recruited gastric cancer patients will be compared.
A prospective comparison of PET/MRI and PET/CT for gastric cancer will be performed,to evaluate the value of PET/MRI in predicting the preoperative staging and resectability of gastric cancer and investigate the role of PET/MRI in gastric cancer diagnosis.The evaluation parameters are the diagnostic accuracy of gastric cancer staging( including the overall accuracy, sensitivity, and specificity) and the receiver operating characteristic (ROC).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Gastric cancer | Each patient will perform a PET/MRI examination,and in the next day,a PET/CT.All the examinations are performed before the operation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PET/MRI | Device | The recruited patients will receive a PET/MRI examination to evaluation the stage and resectability of the cancer. |
|
| Measure | Description | Time Frame |
|---|---|---|
| The results of the PET/MRI and PET/CT examination | Two experienced radiologists independently assess the TNM staging of gastric cancer using preoperative PET/MRI and PET/CT images | 3 days |
| Measure | Description | Time Frame |
|---|---|---|
| Histopathological diagnosis | including definitely T stage in Tx, number of regional lymph node metastasis,result of histologic subtypes of carcinoma,result of other cytological examination. | 5 days |
| Results of CT/Endoscopic ultrasound(EUS) image |
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Inclusion Criteria:
Exclusion Criteria:
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The cohort will recruit from patients diagnosed as gastric cancer and treated in the Department of general surgery.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lin Chen, Master | Contact | 86-13801290395 | chenlinbj@sina.com |
| Name | Affiliation | Role |
|---|---|---|
| Jianxin Cui, Doctor | the Chinese PLA General Hospital | Study Director |
| Yi Liu | the Chinese PLA General Hospital | Principal Investigator |
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| ID | Term |
|---|---|
| D013274 | Stomach Neoplasms |
| ID | Term |
|---|---|
| D005770 | Gastrointestinal Neoplasms |
| D004067 | Digestive System Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D000072078 | Positron Emission Tomography Computed Tomography |
| ID | Term |
|---|---|
| D049268 | Positron-Emission Tomography |
| D014055 | Tomography, Emission-Computed |
| D007090 | Image Interpretation, Computer-Assisted |
| D003952 | Diagnostic Imaging |
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| PET/CT | Device | At the next day of PET/MRI examination,A PET/CT examination will be performed. |
|
|
Experienced radiologists assess definitely T stage in Tx, number of regional lymph node metastasis,with or without distant metastasis.
| 3 days |
| Numerical values of Standard uptake value(SUV) | Standard uptake value(SUV) is defined as the ratio of the image derived radioactivity concentration and the whole body concentration of the injected radioactivity. | 3 days |
| Apparent Diffusion Coefficient(ADC) | Apparent Diffusion Coefficient(ADC) will be measured using a curved Placement of region of interest(ROI) to include the high signal and be read out on ADC maps by Diffusion-weighted magnetic resonance imaging (DWI or DW-MRI) analysis software. | 3 days |
| The expression level of Receptor tyrosine-protein kinase erbB-2(HER2) | Acquire from pathology results | 5 days |
| The expression level of Receptors for vascular endothelial growth factor(VEGFR) | Acquire from pathology results | 5 days |
| Follow-up data | results of conventional imaging examination and tumor biomarkers examination. | at lest 6 months |
| D004066 |
| Digestive System Diseases |
| D005767 | Gastrointestinal Diseases |
| D013272 | Stomach Diseases |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014057 | Tomography, X-Ray Computed |
| D064847 | Multimodal Imaging |
| D011856 | Radiographic Image Enhancement |
| D007089 | Image Enhancement |
| D010781 | Photography |
| D011859 | Radiography |
| D014056 | Tomography, X-Ray |
| D011877 | Radionuclide Imaging |
| D014054 | Tomography |
| D003947 | Diagnostic Techniques, Radioisotope |