Letrozole Versus Laparoscopic Ovarian Drilling in Polycystic Ovary Syndrome

Letrozole Versus Laparoscopic Ovarian Drilling for Clomiphene-resistant Women With Polycystic Ovary Syndrome

Polycystic ovary syndrome is the major cause of anovulatory infertility. Clomiphene citrate is the most commonly used oral agent for ovulation induction in this group, but there are some drawbacks with the use of it.

Inclusion Criteria:

• History of at least one year of infertility either primary or secondary.
• Body mass index: 25-35
• Normal fallopian tubes
• Normal semen analysis of the husband
• Women who will accept to participate in the study

Exclusion Criteria:

• Body mass index above 35
• Contraindication to general anesthesia
• Previous laparoscopic drilling
• Presence of other causes of infertility
• Women who had received metformin, gonadotrophin, oral contraceptives or other hormonal drugs during the preceding 6 months
• Women who intended to start a diet program
• Women who will refuse to participate in the study.