The overall aim of this study is to determine whether non-invasive imaging with myocardial contrast echocardiography using can provide information on the presence and spatial extent of recent myocardial ischemia by non-invasive echocardiographic imaging.

NORMAL CONTROL GROUP

Inclusion Criteria:

• Normal control individuals

Exclusion Criteria:

• History of cardiovascular disease (coronary artery disease, MI, peripheral artery disease)
• allergy to eggs or ultrasound contrast agents
• known or detected right to left shunt
• presence of a wall motion abnormality
• pregnancy

ACS GROUP

Inclusion Criteria:

• Patients with diagnosis of acute coronary syndrome with either unstable angina or non-ST-elevation MI
• Referred for primary percutaneous intervention
• At least 1 high risk features (ST changes, positive troponin, wall motion abnormality)

Exclusion Criteria:

• allergy to eggs or ultrasound contrast agents
• hemodynamic instability or shock
• known or detected right to left shunt
• pregnancy
• multivessel CAD requiring multivessel PCI