IV Acetaminophen and Patent Ductus Arteriosus

The Efficacy of IV Acetaminophen on Patent Ductus Arteriosus Closure in Preterm Infants

This is a randomized controlled trial to evaluate the efficacy of IV acetaminophen versus IV ibuprofen in closing a hemodynamically significant patent ductus arteriosus in preterm infants.

Inclusion Criteria:

• preterm infants 23-30 weeks gestation,
• PDA requiring treatment

Exclusion Criteria:

• infection,
• congenital heart disease,
• genetic syndrome,
• NEC,
• pulmonary hypertension,
• hydrops,
• intestinal perforation,
• grade 3 or 4 IVH,
• serum creatinine >1.5,
• previous treatment with a COX inhibitor.