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This study aims to show whether the hyperglycaemic phases following a treatment with glucocorticoids, as well as blood measurements correlated to high blood glucose levels and insulin resistance, vary significantly between patients with and without gestational diabetes mellitus.
BACKGROUND:
The therapy with glucocorticoids for fetal lung maturation in the case of threatening preterm birth is an long existing part of the obstetric routine procedures. Under this therapy it should not be forgotten, that glucocorticoids can lead to a decrease of the maternal insulin sensitivity as well as they can cause an impaired maternal glucose tolerance.
Therefore a threatening preterm birth as well as the including medical therapy do challenge the glucose metabolism of mother and child.
Gestational diabetes mellitus (GDM) is one of the most common complications during pregnancy, and the numbers are on the rise. GDM is characterized through an insulin resistance during the pregnancy.
High blood glucose level during pregnancy or labour can cause complications like a fetal hypoglycaemia right after birth.
METHODS:
This study includes pregnant women with and without gestational diabetes who are medicated with betamethasone due to threatening preterm birth.
In this study the blood glucose measurements of one week, as well as the measurements of HbA1C, Insulin and Blood Glucose from a blood draw one week after the lung maturation therapy will be considered.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case group | The oral glucose tolerance test that these women undergo in pregnancy between 24+0 and 28+0 showed pathological measurements. | ||
| Control group | The oral glucose tolerance test of these women showed no pathological measurements. |
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| Measure | Description | Time Frame |
|---|---|---|
| Blood glucose measurements | The patient measures their blood glucose level six times a day for seven days. The times of the measurements are before and one hour after every meal. | Seven days after betamethasone medication. |
| Measure | Description | Time Frame |
|---|---|---|
| HbA1C | HbA1C measurements from a blood draw of the patient. | One week after the medication with Betamethasone for lung maturation. |
| Blood Glucose Level | Blood glucose level measurements from a blood draw of the patient. |
| Measure | Description | Time Frame |
|---|---|---|
| Age of the patient in years | Age of the patient in years | At the day of the medication with betamethasone |
| Result of oral glucose tolerance test | Mandatory test in the Austrian Mother-Child-Pass. The data will be collected at the day of the medication with betamethasone. |
Inclusion Criteria:
Exclusion Criteria:
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All participating patients will be pregnant women with a threatening preterm birth admitted to the department of feto-maternal health and obstetrics of the AKH Vienna.
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| Name | Affiliation | Role |
|---|---|---|
| Christian Goebl, MD | AKH Vienna | Study Chair |
| Lara Linsenmeier, Student | Medical University of Vienna | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AKH (General Hospital of) Vienna | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D016640 | Diabetes, Gestational |
| D007333 | Insulin Resistance |
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D003920 | Diabetes Mellitus |
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| One week after the medication with Betamethasone for lung maturation. |
| Insulin level | Insulin level measurements from a blood draw of the patient. | One week after the medication with Betamethasone for lung maturation. |
| The test will be carried out during pregnancy between 24+0 and 28+0 weeks of gestation |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |
| D004700 | Endocrine System Diseases |
| D006946 | Hyperinsulinism |
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |