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To evaluate the mean changes in Endothelial Cell and Corneal pachymetry in eyes that operated under N2O + sevoflurane and O2 + sevoflurane general anesthesia.
40 eyes of 40 patients who had extraocular surgery under general anesthesia will be included in this prospective study. Cell density, Cell variatio, Hexagonality rate and pachymetry specular microscopy results at before surgery and 1 week and 1 month after surgery will be analyzed. O2 (1 l/min) with 50% air and N2O (1 l/min) with 50% air will be applied to each group with flow rate 2 l/min totally, respectively. The duration of surgery will be recorded.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| corneal endothal | Active Comparator | Evaluate the effects of nitrogen protoxide to corneal endothal and compare with oxygen. |
|
| Cell density | Active Comparator | Evaluate the effects of nitrogen protoxide to Cell density and compare with oxygen. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Nitrogen protoxide | Other |
| ||
| Oxygen |
| Measure | Description | Time Frame |
|---|---|---|
| Change of corneal endothal number | Nitrogen protoxide and oxygen may be change this number | after surgery at first day, 1th week and 1th month |
| Change of Cell density rate | Nitrogen protoxide and oxygen may be change this rate | after surgery at first day, 1th week and 1th month |
| Change of Cell variation rate | Nitrogen protoxide and oxygen may be change this rate | at before surgery and 1 week and 1 month after surgery |
| Change of Hexagonality rate | Nitrogen protoxide and oxygen may be change this rate | after surgery at first day, 1th week and 1th month |
| Change of pachymetry specular microscopy results | Nitrogen protoxide and oxygen may be change these results | after surgery at first day, 1th week and 1th month |
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Inclusion Criteria:
Exclusion Criteria:
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| ID | Term |
|---|---|
| D003316 | Corneal Diseases |
| ID | Term |
|---|---|
| D005128 | Eye Diseases |
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| ID | Term |
|---|---|
| D009609 | Nitrous Oxide |
| D010100 | Oxygen |
| ID | Term |
|---|---|
| D009589 | Nitrogen Oxides |
| D005740 | Gases |
| D007287 | Inorganic Chemicals |
| D017672 | Nitrogen Compounds |
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| Other |
|
| D010087 |
| Oxides |
| D017601 | Oxygen Compounds |
| D018011 | Chalcogens |
| D004602 | Elements |