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| Name | Class |
|---|---|
| Jilin University | OTHER |
| Ganzhou City People's Hospital | OTHER |
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Integrative analysis of GBM
The investigators will analyzed proteomes of paired normal brain tissues and GBM, sequenced transcriptomes, perform whole exome sequencing, and single nucleotide polymorphism (SNP) array profiling for triplets, each comprising normal brain tissue, primary GBM carcinoma, and its synchronous matched metastasis, as well as analyzed genomics of GBM characterized previously by The Cancer Genome Atlas (TCGA) to conduct integrated proteogenomic analyses.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Normal brain tissue | Normal brain tissue from GBM patients |
| |
| GBM tissues | GBM tissues from GBM patients |
| |
| Metastasis tissues | Metastasis tissues from GBM patients |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal brain tissue | Other | The investigators will extract total protein, DNA and RNA from the samples. |
|
| Measure | Description | Time Frame |
|---|---|---|
| 5 years overall survival | 5 years |
| Measure | Description | Time Frame |
|---|---|---|
| 5 years disease-free survival | 5 years | |
| 10 years overall survival | 10 years | |
| 10 years disease-free survival |
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Inclusion Criteria:
Exclusion Criteria:
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Patients with GBM
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Da Fu, PhD | Contact | 00-86-21-66301604 | fu800da900@126.com | |
| Yushui Ma, BS | Contact | 00-86-21-66301604 | mayushui2015@126.com |
| Name | Affiliation | Role |
|---|---|---|
| Da Fu, PhD | Shanghai 10th People's Hospital | Principal Investigator |
| Xiaoming Zhong, MD | Ganzhou City People's Hospital | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Shanghai Tenth People's Hospital | Recruiting | Shanghai | Shanghai Municipality | 200072 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 25651787 | Result | Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer J Clin. 2015 Mar;65(2):87-108. doi: 10.3322/caac.21262. Epub 2015 Feb 4. |
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The investigators are willing to share data.
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| ID | Term |
|---|---|
| D005909 | Glioblastoma |
| ID | Term |
|---|---|
| D001254 | Astrocytoma |
| D005910 | Glioma |
| D018302 | Neoplasms, Neuroepithelial |
| D017599 | Neuroectodermal Tumors |
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| 10 years |
| D009373 |
| Neoplasms, Germ Cell and Embryonal |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
| D009375 | Neoplasms, Glandular and Epithelial |
| D009380 | Neoplasms, Nerve Tissue |