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Investigation of efficacy of vigabatrin in refractory autoimmune encephalitis patients
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vigabatrin treatment group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vigabatrin 500 MG | Drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Seizure frequency reduction | 50% reduction - favorable outcome | 3 month of vigabatrin administration |
| Measure | Description | Time Frame |
|---|---|---|
| Modified Rankin Scale | 3 month of vigabatrin administration | |
| Quality of life (Quality of Life in Epilepsy Inventory, QOLIE-31) | after 3 month of vigabatrin administration | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| KON CHU, MD, PhD | Seoul National University Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Seoul National University Hospital | Seoul | South Korea |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 18954912 | Background | Bjurstom H, Wang J, Ericsson I, Bengtsson M, Liu Y, Kumar-Mendu S, Issazadeh-Navikas S, Birnir B. GABA, a natural immunomodulator of T lymphocytes. J Neuroimmunol. 2008 Dec 15;205(1-2):44-50. doi: 10.1016/j.jneuroim.2008.08.017. Epub 2008 Oct 26. | |
| 20940040 | Background | Rossi S, Muzio L, De Chiara V, Grasselli G, Musella A, Musumeci G, Mandolesi G, De Ceglia R, Maida S, Biffi E, Pedrocchi A, Menegon A, Bernardi G, Furlan R, Martino G, Centonze D. Impaired striatal GABA transmission in experimental autoimmune encephalomyelitis. Brain Behav Immun. 2011 Jul;25(5):947-56. doi: 10.1016/j.bbi.2010.10.004. Epub 2010 Oct 20. |
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| ID | Term |
|---|---|
| D020274 | Autoimmune Diseases of the Nervous System |
| ID | Term |
|---|---|
| D009422 | Nervous System Diseases |
| D001327 | Autoimmune Diseases |
| D007154 | Immune System Diseases |
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| ID | Term |
|---|---|
| D020888 | Vigabatrin |
| ID | Term |
|---|---|
| D005680 | gamma-Aminobutyric Acid |
| D000613 | Aminobutyrates |
| D002087 | Butyrates |
| D000144 | Acids, Acyclic |
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| Depression (Beck Depression Inventory®-II) |
| 3 month of vigabatrin administration |
| Cognition (Mini-Mental State Examination-Korean) | 3 month of vigabatrin administration |
| Sleep quality (Pittsburgh Sleep Quality Assessment) | 3 month of vigabatrin administration |
| D002264 |
| Carboxylic Acids |
| D009930 | Organic Chemicals |
| D000596 | Amino Acids |
| D000602 | Amino Acids, Peptides, and Proteins |