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the investigators aim is to investigate the effect of continuous preperitoneal bupivacaine wound infiltration versus epidural analgesia on the inflammatory cytokines response following radical cytectomy
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| epidural group | Active Comparator | an epidural catheter will be inserted under sterile conditions through the T9- 12 interspace using the 'loss-of-resistance' technique. The catheter will be advanced 4 cm cephalad. . |
|
| preperitoneal group | Active Comparator | preperitoneal catheters will be placed in the subfascial (ie, pre-peritoneal) space under direct vision. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| epidural catheter | Device |
|
| |
| preperitoneal catheter |
| Measure | Description | Time Frame |
|---|---|---|
| changes in the level of inflammatory cytokines in pg /ml | Blood samples taken all over the 24-hr. period were collected in plasma tubes containing ethyl-enediamine-tetra-acectic (EDTA), centrifuged and stored at 20â—‹c for assessment of Plasma concentrations plasma IL 1, IL 6, IL10 and TNF to assess inflammatory cytokines | 24 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Visual Analog Scale at rest and on coughing | pain intensity was assessed using a 10-cm VAS (0 = no pain and 10 = worst imaginable pain) | 24 hours |
| opioid side-effects | observation of side effects and record incidence as nausea, vomiting and itching |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| fatma el sherif, M.D | south Egypt cancer institute - assuit university | Principal Investigator |
| Ahmad M Abd El-Rahman, M.D | Lecturer of anesthesia, icu, and pain management | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| South Egypt Cancer instIitute | Asyut | 171516 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30829734 | Derived | Othman AH, Ahmed DG, Abd El-Rahman AM, El Sherif FA, Mansour S, Aboeleuon E. Effect of Preperitoneal Versus Epidural Analgesia on Postoperative Inflammatory Response and Pain Following Radical Cystectomy: A Prospective, Randomized Trial. Clin J Pain. 2019 Apr;35(4):328-334. doi: 10.1097/AJP.0000000000000679. |
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| ID | Term |
|---|---|
| D000008 | Abdominal Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
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| Device |
|
|
| 24 hours |
| patient satisfaction | scale ranging 1-4 :unsatisfactory, regular, satisfactory and excellent) | 24 hours |