Acute Effect of Agiotensin-(1-7) in Healthy and Hypertensive Subjects

Acute Effect of Agiotensin-(1-7) on Bood Pressure and Heart Rate in Healthy and Hypertensive Subjects

In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.

Healthy Group Inclusion Criteria:

• arterial pressure <140/90 mmHg
• body mass index (BMI) between 18,5 and 29 Kg/m2

Hypertensive Group Inclusion Criteria:

• anti-hypertensive drug treatment
• ambulatory blood pressure monitoring (ABMP) >130/85 mmHg
• body mass index between 18,5 and 29 Kg/m2

Healthy Group Exclusion Criteria:

• drug treatment
• recent surgeries
• pregnancy
• previous cardiovascular events
• high performance athletes
• dislipidemia
• diabetes
• renal injury
• obesity (BMI above 30 kg/m2)
• alcoholism
• smoking.

Hypertensive Group Exclusion Criteria:

• recent surgeries
• pregnancy
• beta-blockers drug treatment
• previous cardiovascular events
• high performance athletes
• dislipidemia
• diabetes
• renal injury
• obesity (BMI above 30 kg/m2)
• alcoholism
• smoking