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In the modern concept of Renin-angiotensin System, Angiotensin-(1-7) plays a key role and demonstrates promising therapeutic potential due to it is generally opposite effects to Angiotensin II. The aim is to evaluate the effect of Ang-(1-7) acute administration on systolic and diastolic blood pressure (SBP and DBP) and heart rate (HR) in healthy and hypertensive subjects.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Healthy Subjects | Experimental | Placebo and Angiotensin-(1-7) acute infusion |
|
| Hypertensive Subjects | Experimental | Placebo and Angiotensin-(1-7) acute infusion |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Angiotensin 1-7 | Drug |
|
| |
| Measure | Description | Time Frame |
|---|---|---|
| Absence of adverse effects after Ang-(1-7) acute administration | Along 25 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Blood Pressure Changes after Ang-(1-7) administration | absence of measure changes in blood pressure or heart rate (increase or decrease) | Recording along 24 hours |
| Ang-(1-7) effects on Blood Pressure Variability |
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Healthy Group Inclusion Criteria:
Hypertensive Group Inclusion Criteria:
Healthy Group Exclusion Criteria:
Hypertensive Group Exclusion Criteria:
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| ID | Term |
|---|---|
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| C118790 | angiotensin I (1-7) |
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| Placebo |
| Other |
|
Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration
| Along 1 hours after Ang-(1-7) acute administration |
| Heart Rate Changes after Ang-(1-7) administration | Recording along 24 hours |
| Ang-(1-7) effects on Heart Rate Variability | Response of autonomic nervous system, registered for 1 hours, after Ang-(1-7) acute administration | Along 1 hours after Ang-(1-7) acute administration |