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The purpose of this project is to present the outcomes of patients with giant cell tumor of bone (GCTB) who were treated with surgery and/or medical treatment in a single institution.
The investigators retrospectively review patients treated for GCTB of the extremities between 1990 and 2013 in a single institution. We evaluate the recurrence free survival rate after surgical and medical treatment of patients with GCTB of the extremities to determine the influence of the surgical approach, denosumab therapy, local tumor presentation, and demographic factors on the risk of recurrence.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| curettage and resection | Procedure | the investigators analyzed patients with giant cell tumor of bone who underwent curettage or resection with or without denosumab administration |
|
| Measure | Description | Time Frame |
|---|---|---|
| local recurrence rate after surgical and medical treatment | within the first 36 months after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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patients with giant cell tumor of bone treated in a single institution
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| Name | Affiliation | Role |
|---|---|---|
| Davide Donati, MD | Istituto Ortopedico Rizzoli | Study Director |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 30099641 | Derived | Tsukamoto S, Mavrogenis AF, Leone G, Righi A, Akahane M, Tanzi P, Kido A, Honoki K, Tanaka Y, Donati DM, Errani C. Denosumab does not decrease the risk of lung metastases from bone giant cell tumour. Int Orthop. 2019 Feb;43(2):483-489. doi: 10.1007/s00264-018-4085-6. Epub 2018 Aug 11. |
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publish a manuscript in international medical journal
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| ID | Term |
|---|---|
| D018212 | Giant Cell Tumor of Bone |
| D001859 | Bone Neoplasms |
| D005870 | Giant Cell Tumors |
| ID | Term |
|---|---|
| D009372 | Neoplasms, Connective Tissue |
| D018204 | Neoplasms, Connective and Soft Tissue |
| D009370 | Neoplasms by Histologic Type |
| D009369 | Neoplasms |
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| ID | Term |
|---|---|
| D003475 | Curettage |
| D000069448 | Denosumab |
| ID | Term |
|---|---|
| D013514 | Surgical Procedures, Operative |
| D061067 | Antibodies, Monoclonal, Humanized |
| D000911 | Antibodies, Monoclonal |
| D000906 | Antibodies |
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| D018213 | Neoplasms, Bone Tissue |
| D009371 | Neoplasms by Site |
| D001847 | Bone Diseases |
| D009140 | Musculoskeletal Diseases |
| D007136 | Immunoglobulins |
| D007162 | Immunoproteins |
| D001798 | Blood Proteins |
| D011506 | Proteins |
| D000602 | Amino Acids, Peptides, and Proteins |
| D012712 | Serum Globulins |
| D005916 | Globulins |