Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The planned contrast compares the model-predicted change in DBP from index to 365 days in Telehealth care vs. index to 365 days in clinic based care.

The threshold for statistical significance was p<0.05

adjusted for baseline SBP, baseline DBP, baseline age, sex, Asian race

Random coefficients model predicted all EHR-documented DBPs from treatment group, days elapsed from index to each DBP (time) and treatment group by time with random clinic and patient intercepts.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood pf reporting high satisfaction at 6 months relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood pf reporting high satisfaction at 6 months relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The risk ratio compares the likelihood of current smoking at 12 months in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

unadjusted

Random coefficients model predicted the likelihood that smoking was current 12 months by treatment group with random clinic intercept.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the side effect was a problem at 6m relative to baseline in Telehealth vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the activity is helpful at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the activity is helpful at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the activity was helpful at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the activity is helpful at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the activity is helpful at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting the burden was a problem at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Best Practice Clinic-Based Care intervention.

Best Practice Clinic-Based Care: Relies primarily on the physician-medical assistant dyad and face-to-face visits to promote:

1. Improved recognition of uncontrolled BP at primary care encounters,
2. Therapeutic action to address uncontrolled BP at primary care encounters,
3. Reliable follow-up visits to re-assess uncontrolled BP every 2-4 weeks.

Patients with uncontrolled hypertension who receive primary care in clinics assigned to the Telehealth Care intervention.

Telehealth Care: All elements of Clinic-Based Care are performed, plus a telemonitoring and pharmacist case management program is offered, specifically:

1. Referral to care by MTM pharmacist or Nurse Practitioner and receiving a home blood pressure telemonitoring device
2. Systematic home BP telemonitoring with data transmitted into patient medical record
3. Systematic home-based care by pharmacist or nurse practitioner via telephone and/or secure email

The interaction RR compares the likelihood of reporting very/extremely confident at 6m relative to baseline in Telehealth care vs. clinic based care

The threshold for statistical significance was p<0.05

adjusted for baseline DBP, baseline age, sex

Random coefficients model predicted baseline and 6 month patient-reported outcome from treatment group, time point and treatment group by time with random clinic intercept and patient scale parameter.