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The purpose of this study is to check if patients, but also relatives (as they share familial and genetic risk factors), are having more difficulties in regulating a spontaneous, pleasant physical effort (doing "too much") compared to healthy controls, and if physical efforts are participating to core symptoms of anorexia nervosa, such as more appetite (instead of less), less pain, more abnormal body image, and less cognitive flexibility.
Such a result could help to further understand the role of difficulties with physical exercise as part of the phenotype of anorexia nervosa.
This is a three steps protocol. First, patients (with anorexia nervosa), controls (with no eating disorder) and first degree relatives (with no eating disorder) will be tested for emotional accuracy (seing faces on a screen with different core emotions), pain threshold (how long they can support a cold probe), body size (how they see themselves), appetite and cognitive flexibility (a test where the capacity to change rules during a game is done easily or not).
Then all subjects will do a standardized physical exercise which represents an effort with the equivalent level of energy for each participants as being chosen according to each level of competency (assessed through the "maximal aerobic power").
The third step consists in the repetition of (nearly) initial tests.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Anorexia nervosa | Other | Patients with DSM-5 criteria of "anorexia nervosa" |
|
| First degree relatives | Other | First degree relatives (of patients suffering from anorexia nervosa) with no eating disorder |
|
| Controls (with no eating disorder) | Other | Other |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Clinical and biological examination, Saliva (or blood) test Glycemia, thermal test, cognitive and bike tests, questionnaires | Other | Clinical and biological examination, Saliva (or blood) test, glycemia, thermal test, cognitive and bike tests, questionnaires |
| Measure | Description | Time Frame |
|---|---|---|
| Physical power | Comparison inter and intra individual of the subjective and objective power to the subjects during a typical physical bike test. | Day 0 |
| Measure | Description | Time Frame |
|---|---|---|
| Pain threshold | This threshold is based on the minimum temperature that the patient is able to suppor (the probe is placed on the skin of the forarm, and the temperature reduces its temperature every 10 seconds), knowing that the machine is not getting to temperatures that can be damageable. Comparison before and after bike test | Day 0 |
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Inclusion Criteria:
Patients :
First degree relatives :
Controls :
Exclusion Criteria:
All groups :
Related and controls :
Diagnosis of ED (eating disorders) in the EDI-2 and in the MINI
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philip GORWOOD, MD, PhD | Contact | 00 33 45 65 86 39 | p.gorwood@ch-sainte-anne.fr | |
| Marie GODARD | Contact | 00 33 1 45 65 77 28 | s.dorocant@ch-sainte-anne.fr |
| Name | Affiliation | Role |
|---|---|---|
| Philip GORWOOD, MD, PhD | CHSA | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre Hospitalier Sainte Anne | Recruiting | Paris | 75014 | France |
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| Clinical examination, Glycemia, saliva (or blood) test, thermal test, cognitive and bike tests, questionnaires | Other | Clinical examination, Glycemia, saliva (or blood) test, thermal test, cognitive and bike tests, questionnaires |
|
| Wellbeing self-questionnaire |
Comparison before and after bike test |
| Day 0 |
| Hunger Visual analogical scale | Comparison before and after bike test | Day 0 |
| PANAS score (self-questionnaire) | Emotions. Comparison before and after bike test | Day 0 |
| Hunger Visual analogical scale | Apetite. Comparison before and after bike test | Day 0 |
| Performance on the Briton cognitive test (number of errors) | Mental flexibility. Comparison before and after bike test | Day 0 |
| Performance on cognitive tests (speed, number of errors), before versus after the exercise, in the three groups. | Tests. Performance on cognitive tests (speed, number of errors), before versus after the exercise, in the three groups. | Day 0 |
| Genetical analysis | 10 candidate genes will be analyzed (following the collection of blood or saliva) assessing the frequency of their main alleles (variants), looking for a significant difference of allele frequency between the 3 groups. | Day 0 |
| ID | Term |
|---|---|
| D000856 | Anorexia Nervosa |
| ID | Term |
|---|---|
| D001068 | Feeding and Eating Disorders |
| D001523 | Mental Disorders |
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| ID | Term |
|---|---|
| D011795 | Surveys and Questionnaires |
| D012149 | Restraint, Physical |
| D001786 | Blood Glucose |
| ID | Term |
|---|---|
| D003625 | Data Collection |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D017531 | Health Care Evaluation Mechanisms |
| D011787 | Quality of Health Care |
| D017530 | Health Care Quality, Access, and Evaluation |
| D011634 | Public Health |
| D004778 | Environment and Public Health |
| D032763 | Behavior Control |
| D013812 | Therapeutics |
| D007103 | Immobilization |
| D005947 | Glucose |
| D006601 | Hexoses |
| D009005 | Monosaccharides |
| D000073893 | Sugars |
| D002241 | Carbohydrates |
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