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It is the aim of this study to detect the effect of Betamethasone on the maternal inflammatory parameters C-reactive protein (CRP) and leukocytes of a pregnant woman under threat of preterm delivery, for example because of a cervical infection.
BACKGROUND
Cortisone influences the maternal number of leukocytes and CRP of a pregnant woman. Because of that, it is difficult to know if the medical treatment of an infection was successful and accordingly if the diagnosis was justified.
METHODS
In this study, the blood results of 75 pregnant women under threat of preterm delivery (week of gestation 23+0 to 34+6), treated with Betamethasone will be analysed. 65 pregnant women without complications serve as control group.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Case Group | 75 woman between the age of 18 to 50 years, week of gestation 23+0 - 34+6, threatening preterm delivery, application of Betamethasone | ||
| Control Group | 65 woman between the age of 18 to 50 years, week of gestation 23+0 - 34+6, no threatening preterm delivery |
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| Measure | Description | Time Frame |
|---|---|---|
| CRP | The CRP values in mg/dL before and 48h after the first Betamethasone application | 48h |
| Measure | Description | Time Frame |
|---|---|---|
| Leucocytes | The Leucocyte values in G/L before and 48h after the first Betamethasone application | 48h |
| Measure | Description | Time Frame |
|---|---|---|
| Body Mass Index (BMI) | Body Mass Index (BMI) in kg/m^2 is calculated to test for influence on inflammatory parameters in both groups (case and control) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Weight |
Inclusion Criteria:
Exclusion Criteria:
infectious diseases f.e. hepatitis B or C, HIV
diseases of the thyroid gland
75 Patients facing preterm labour 65 Patients acting as a control group, without preterm labor
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Pregnant woman admitted to the department of feto-maternal health and obstetrics
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| Name | Affiliation | Role |
|---|---|---|
| Maria Kastanek | Medical University Vienna | Principal Investigator |
| Florian Frommlet, DI. Dr. | Medical University Vienna | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| General Hospital Vienna | Vienna | 1090 | Austria |
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| ID | Term |
|---|---|
| D047928 | Premature Birth |
| ID | Term |
|---|---|
| D007752 | Obstetric Labor, Premature |
| D007744 | Obstetric Labor Complications |
| D011248 | Pregnancy Complications |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
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- blood samples
Weight in kilogram (kg) is taken from the medical record to calculate the BMI in both groups (case and control)
| single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Height | Size in meters (m) is taken from the medical record to calculate the BMI in both groups (case and control) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| CRP Control Group | CRP values in mg/dL of patients belonging to the control group | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Leucocytes Control Group | Leucocyte values in G/L of patients belonging to the control group | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Patients with Allergies | information about the patients allergie status (allergies yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Patients with Diabetes | information about the patients diabetes status (diabetes yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| Smoking Habits | information about the patients smoking status (smoking yes or no) is taken from the medical record to test for influence on inflammatory parameters in both groups (case and control) | single point in the time frame between week of gestation 23+0 - 34+6, no fixed day |
| D000091642 | Urogenital Diseases |