With the potential to address evaporative dry eye, Liposic and Tears Naturale Forte have been developed in which phospholipid liposomes are delivered to the tear film via the surface of the closed eyelid. This study compare the effects of Liposic and Tears Naturale Forte application on the lipid and stability of the tear film in dry eye patients.

Inclusion Criteria:

• Minimum age of 20 years(range from 20 year to 25 years)
• The value of OSDI is over 12
• NBUT is less 5 seconds
• Schirmer 1 test is less 10mm
• The basical lipid layer grade is 1-2

Exclusion Criteria:

• Any corneal,conjunctival, or eyelid abnormalities; conjunctivitis; current ocular infection; photophobia that may cause reflex tearing or difficulty in evaluating the patient's lipid layer;
• Known allergic sensitivity to any of the ingredients in Liposic or Tears Naturale Forte