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Muscle size declines at around 0.5-1% per year after 50 years of age, with muscle strength declining up to twice as fast as muscle size. This may eventually lead to loss of independence if tasks of daily living become too strenuous to be performed safely. Exercise is recognized as a safe and effective means to counteract muscle loss during aging, however access to gym equipment may be logistically challenging or unpalatable to older adults. This research is designed to investigate the effect of 28 days of home-based leg exercise that doesn't require exercise equipment or supervision (exercise snacking), accompanied with a daily protein supplement in the form of commercially available yogurt, on the skeletal muscle health (i.e. function and size) of independent, community-dwelling older adults. To achieve this, two groups will be compared; one group will undertake exercise snacking and consume a 150 g yogurt with the breakfast meal for four weeks, with the second group only receiving the daily yogurt with no exercise snacking.
The study will require potential participants to undergo an eligibility screening with a member of the research team, followed by a period of seven days of habitual activity monitoring and 3 days of diet recording. Eligible participants will be allocated into study groups by way of minimization based on sex, age, BMI, and number of sit-to-stands performed in a minute. Participants will undertake two familiarisation sessions with strength, power, neural drive, and balance tests at least seven days apart, the first following eligibility screening and the second familiarisation session at least five days before the first main trial.
Thereafter, both groups will undertake a main trial the day before commencing 28 days of daily 150 g yoghurt supplement with the breakfast meal, with the exercise snacking group (ES) also undertaking two bouts of exercise snacking a day. The main trial will include measures of leg muscle function and neural drive, standing and single leg balance, and movement co-ordination during tasks of everyday ambulation. Participants will wear a physical activity monitor and pedometer for the seven days and record diet for three days during the last week of the intervention. The day after the intervention period, a follow-up main trial will be conducted as per the first main trial, followed by an optional qualitative interview regarding participant's experience of the trial.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Exercise Snacking Group | Experimental | For 28 days, this group will be asked to perform two 'exercise snacks' a day; once in the morning and once in the evening. They will also be asked to consume 150 g of yogurt with the breakfast meal. The yogurt will be provided by the researchers. |
|
| Yogurt Only Group | Other | For 28 days, this group will be asked to consume 150 g of yogurt with the breakfast meal. The yogurt will be provided by the researchers. Apart from consuming the yogurt, this group will be asked to continue their normal lifestyle. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Exercise Snacking | Behavioral | Each bout of exercise snacking consists of 5 exercise. Each exercise is performed for one minute, with aim of completing as many repetitions as possible of that exercise in that minute. One minute of rest is observed between each exercise of the exercise snack. The five exercises are; sit-to-stand from a chair, marching on the spot, seated knee extensions alternating legs, standing knee bends alternating legs, and standing calf raises. The sit-to-stand exercise is always performed first, with the number of repetitions achieved recorded, and subsequent exercises performed in any order without recording of repetitions. Two exercise snacks are completed each day for 28 days; once in the morning and once in the evening, or at least separated by 2 hours. |
| Measure | Description | Time Frame |
|---|---|---|
| 60 second sit to stand test | The participant is asked to stand up from sitting in a chair whilst keeping their arms folded across their chest, then return to the seated position as many times as possible in a minute. | 28 days- change from pre- to post- intervention period |
| Measure | Description | Time Frame |
|---|---|---|
| Lower limb muscle power | Measured during leg pressing | 28 days- change from pre- to post- intervention period |
| Lower limb movement outcome variability | Measured during leg pressing |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Keith Stokes, PhD | University of Bath | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Bath | Bath | Avon | BA2 7AY | United Kingdom |
Individual participant data will not be shared with other researchers
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| ID | Term |
|---|---|
| D015014 | Yogurt |
| ID | Term |
|---|---|
| D043302 | Cultured Milk Products |
| D008892 | Milk |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
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| Yogurt | Dietary Supplement | Participants are asked to consume 150 g of yogurt (Arla, Skyr- natural flavour) with their breakfast meal. Participants may substitute the yogurt for another part of their regular breakfast, or add the yogurt to their regular breakfast, with participants asked to record a log book of daily yogurt consumption and to complete a three day food diary during the last week of the 28 day intervention period. |
|
| 28 days- change from pre- to post- intervention period |
| Lower limb muscle cross-sectional area | Measured using peripheral quantitative computed tomography at 66% distal calf length and 25% and 50% distal thigh length | 28 days- change from pre- to post- intervention period |
| Lower limb muscle cross-sectional tissue density | Measured using peripheral quantitative computed tomography at 66% distal calf length and 25% and 50% distal thigh length | 28 days- change from pre- to post- intervention period |
| Body composition | Measured using Dual Energy X-ray Absorptiometry | 28 days- change from pre- to post- intervention period |
| Gastrocnemius and quadriceps muscle fibre pennation angle | Measured using ultrasonography at 66% distal length of calf length and 50% distal thigh length | 28 days- change from pre- to post- intervention period |
| Gastrocnemius and quadriceps muscle fibre length | Measured using ultrasonography at 66% distal length of calf length and 50% distal thigh length | 28 days- change from pre- to post- intervention period |
| Postural sway during standing balance with eyes open and closed | Measured using a force plate | 28 days- change from pre- to post- intervention period |
| Single leg balance | Measured using the Y-balance test | 28 days- change from pre- to post- intervention period |
| Six minute walk test | The participant will be asked to walk as many times between two cones places 15 meters apart as possible in six minutes. | 28 days- change from pre- to post- intervention period |
| Movement co-ordination during walking and sit to stands | Measured by Qualisys motion capture and force plates | 28 days- change from pre- to post- intervention period |
| Central drive of the plantar flexors | Measured through the interpolated twitch technique | 28 days- change from pre- to post- intervention period |
| D010829 |
| Physiological Phenomena |
| D000074421 | Fermented Foods |
| D003611 | Dairy Products |
| D005502 | Food |
| D019602 | Food and Beverages |