Optimizing Protein Intake and Nitrogen Balance in Adult Critically Ill Patients

Optimizing Protein Intake and Nitrogen Balance in Adult Critically Ill Patients: a Randomized Controlled Trial (OPINiB STUDY)

The purposes of the study are:

• To strictly ensure the appropriate level of protein and caloric provision in critical illness, according to the latest literature recommendation;
• To determine if an association exists between protein intake and nitrogen balance in the context of a nutrition with appropriate protein provision based on the latest literature recommendations, rather than in a standard diet with a caloric target weight-based. Creatinine clearance will also be evaluated to determine if there is any harmful effect to the kidney secondary to an elevated BUN.
• To determine if there is a difference in ICU mortality rate between the current nutrition standard and a hyperproteic nutrition protocol.

Inclusion criteria:

• Age > 18 years
• Receiving PN and/or EN nutrition
• Indwelling urinary catheter
• Mechanically ventilated patients

Exclusion criteria:

• Age < 18 years
• Chronic renal or hepatic failure
• Current or history (past 6 months) of GI bleeding
• BMI >30 kg/m2 o <18 kg/m2
• Terminally ill patients
• Pregnancy