Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

Reactions to Reduced Nicotine Cigarettes in Young Adult Low-Frequency Smokers

The purpose of this study is to evaluate reactions to, and choices to self-administer, cigarette smoke with varying nicotine content among low-frequency, non-dependent adolescent/young adult smokers between the ages of 15-25 years.

Participants will undergo three sessions in which their reactions to fixed doses of smoke from investigational cigarettes with three different nicotine contents (15.8 mg/gram of tobacco, 2.5 mg/g, and .4 mg/g) will be assessed. Following the third fixed-dose session, participants will return to the lab to choose one of the cigarettes to self-administer.

Inclusion Criteria:

• generally healthy
• between the ages of 15-25
• use nicotine or tobacco products between 1-15 days/month for at least 6 months
• smokes at least 5 cigarettes/month
• no unstable or significant medical or psychiatric conditions
• breath alcohol value=0.000
• able to provide contact information for two individuals who can corroborate smoking status

Exclusion Criteria:

• use of illegal drugs as measured by urine drug screen (excluding THC)
• serious quit attempt in the past 3 months
• plans to quit smoking in the next 2 months
• current use of nicotine replacement therapy or other tobacco cessation products
• inability to attend all required experimental sessions
• blood pressure >160/100 mmHg
• pregnant, trying to become pregnant, or breastfeeding