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| ID | Type | Description | Link |
|---|---|---|---|
| 2014-A00825-42 | Other Identifier | Agence nationale de Sécurité des Médicaments |
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Bipolar disorder is a major health concern. Intercritical periods are marked with residual symptoms, both thymic and cognitive, which affects quality of life of patients, but also the quality of observance. The implementation of cognitive remediation programs could be interesting. The aim of this study is to evaluate the overall performance on euthymic bipolar patients with memory complaints included in the program named "COGMED", targeting the working memory.
The impact of this program on compliance, quality of life, and memory complaints will be evaluated.
The investigator will measure whether there is a correlation between working memory and overall performances.
Finally, the investigator will try to achieve a profile of bipolar patients in whom the Cogmed program is particularly effective on a plan of overall performance.
Patients with bipolar disorder and memory complaints will be recruited.
Two visits :
Between the two visits the patient will benefit of COGMED program, at home, during 5 weeks.
COGMED is a remediation cognitive program, based on working memory, consisting on daily exercises at home on a computer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| COGMED program | Experimental | Cognitive remediation using COGMED program on bipolar euthymic patients with memory complaints |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| COGMED program | Behavioral | Patient should connect on his computer at home, 5 times a week, for 5 weeks. Every day, the patient has to do 8 exercises for a total duration of 30 to 45 minutes. In total, the patient will have to complete 25 sessions. The difficulty level of the proposed items adjust automatically to the patient's maximum capacity to compel him to provide a cognitive effort. A progression index assesses the progress made by the patient. Every week, the investigator will call the patient for 10 minutes in order to gather the patient's feelings, his difficulties, provide some advice and encourage him. The investigator will have to analyze the results of curves available for each event, as well as the patient's progress index. |
| Measure | Description | Time Frame |
|---|---|---|
| Evolution of the global functioning between the inclusion and the end of the program | evaluation of variation of global functioning will be realized by the Functioning Assessment Short Test (FAST) scale after COGMED program. | At 4 weeks |
| Evolution of the global functioning between the inclusion and the end of the program | evaluation of variation of global functioning will be realized by the Functioning Assessment Short Test (FAST) scale after COGMED program | At 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Observance | Evaluation of variation of patient's compliance by Medication Adherence Rating Scale (MARS) score after COGMED program. | At the inclusion and 4 to 6 weeks until the end of the program COGMED (11 to 13 weeks after inclusion) |
| Quality of life |
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Inclusion criteria:
Exclusion criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Emilie OLIE, MD PhD | Contact | +33 4 67 33 85 81 | e-olie@chu-montpellier.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Montpellier University Hospital | Recruiting | Montpellier | 34295 | France |
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| ID | Term |
|---|---|
| D001714 | Bipolar Disorder |
| ID | Term |
|---|---|
| D000068105 | Bipolar and Related Disorders |
| D019964 | Mood Disorders |
| D001523 | Mental Disorders |
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|
Evaluation of variation of quality of life by Short Form (36) Health Survey (SF-36) score after COGMED program. |
| At the inclusion and 4 to 6 weeks until the end of the program COGMED (11 to 13 weeks after inclusion) |
| Correlation between working memory and global functioning | Searching a statistical correlation between global functioning (using FAST) and working memory (using neuropsychological tests) | At the inclusion and 4 to 6 weeks until the end of the program COGMED (11 to 13 weeks after inclusion) |
| Memory complaints | Variations on memory complaints will be evaluated by Mac Nair Scale score before and after COGMED program. | At the inclusion and 4 to 6 weeks until the end of the program COGMED (11 to 13 weeks after inclusion) |