EGFR-TKI Resistance Profile in Chinese Patients With Advanced EGFRm+ NSCLC

A Prospective Multi-center Study to Investigate the EGFR-TKI Resistance Profile in Chinese Patients With Advanced EGFRm+ NSCLC

A Prospective Multi-center Study to Investigate the EGFR-TKI Resistance Profile in Chinese Patients with Advanced EGFRm+ NSCLC

Patients with EGFR mutation and presented secondary resistance to prior first-generation EGFR-TKI should have received biopsy of at least on progressed lesions and are able to provide tissues for pathological examination and NGS testing.All enrolled patients will be followed up to clinical outcome (treatments, tumor response, survival, etc).

Inclusion Criteria:

• Provision of informed consent prior to any study specific procedures.
• Male or female patients aged 18 years and older.
• Histological confirmation of stage IIIB/IV NSCLC.
• Documented EGFR mutation positive .
• WHO Performance Status 0, 1 or 2

Exclusion Criteria:

• Any other significant clinical disorder or laboratory finding that made it undesirable for the patient to participate in the study.
• Previous (within 6 months) or current treatment with AZD9291.