Plasma-cell post-transplantation lymphoproliferative disorders (PC-PTLD) are rare monomorphic PTLD divided into plasma cell myeloma (PCM) and plasmacytoma-like lesion (PLL) PTLD. To date, there is no exhaustive published cytogenetic data on PC-PTLD. The investigators report array-based comparative genomic hybridization (aCGH) of 10 cases of PCM and PLL-PTLD.

Inclusion Criteria:

• WHO classification 2008 as monomorphic PCM (plasma cell myeloma) or PLL (plasmacytoma like lesion) / PTLD (post transplantation lymphoproliferative disorders).

Exclusion Criteria:

• Other than PCM or PLL PTLD at diagnosis

We conducted a retrospective analysis between 1990 and 2012 of all consecutive cases of PCM and PLL-PTLD collected in the Centre Hospitalier Lyon Sud (CHLS, 6 cases) and in Necker - Enfants Malades Hospital in Paris (4 cases). There were 4 females and 6 males. Among the 8 adults, 6 had received a kidney transplant, 1 a heart transplant and one a lung transplant. Among the 2 children, one had received a heart transplant and one an allogeneic stem cell transplantation with a matched unrelated donor. Immunosuppressive regimens were heterogeneous.