The purpose of this study is to determine whether additional therapy with i-ACT system is effective in the training of functional skills in persons with central neurological diseases (e.g. multiple sclerosis, stroke, spinal cord injury, etc.).

Inclusion Criteria:

• Medical diagnosis of central nervous system disease (e.g. multiple sclerosis, stroke, spinal cord, etc.)
• Be able to understand and respond to questions in Dutch
• Actively involved in a rehabilitation programme in the participating rehabilitation centres
• Have a dysfunction in upper and/or lower limb and/or core stability
• Specifically for multiple sclerosis: min. of one month without corticosteroids
• Specifically for stroke and spinal cord: min. 3 months post injury

Exclusion Criteria:

• Severe spasticity which prevent performing basic functional exercises
• Severe cognitive and communicative impairment which prevent the person to understand and respond to Dutch instructions
• Severe visual impairment, e.g. blindness, cataract, etc.
• Pregnancy
• Persons who use an electrical wheelchair, who can not transfer safely into a normal chair and perform the exercises