Inclusion Criteria:
- Informed consent by a parent or guardian prior to any study-related procedures
- When applicable, informed assent (as deemed appropriate by the Institutional Review Board) by the participant prior to any study-related procedures
- Male or female infant 4 to <12 months corrected gestational age or child or adolescent aged 1 year through 15 years
- Current history of SBS as a result of major intestinal resection (eg, due to necrotizing enterocolitis, midgut volvulus, intestinal atresia, or gastroschisis)
- Short bowel syndrome that requires PN/IV support that provides at least 30% of caloric and/or fluid/electrolyte needs
- Stable PN/IV support, defined as:
For infants 4 to <12 months corrected gestational age: Inability to significantly reduce PN/IV support, usually associated with minimal or no advance in enteral feeds (ie, 10% or less change in PN or advance in feeds) for at least 1 month prior to and during screening, as assessed by the investigator.
For children 1 to 15 years of age:
Inability to significantly reduce PN/IV support, usually associated with minimal or no advance in enteral feeds (ie, 10% or less change in PN or advance in feeds) for at least 3 months prior to and during screening, as assessed by the investigator.
Transient instability for events such as interruption of central access or treatment of sepsis is allowed if the PN/IV support returns to within 10% of baseline prior to the event.
- Sexually active female participants of childbearing potential must use medically acceptable methods of birth control during and for 4 weeks following the last dose of investigational product.
Exclusion Criteria:
- Participants who are not expected to be able to advance oral or tube feeding regimens
- Serial transverse enteroplasty or any other bowel lengthening procedure performed within 3 months of screening
- Known clinically significant untreated intestinal obstruction contributing to feeding intolerance and inability to reduce parenteral support
- Unstable absorption due to cystic fibrosis or other known DNA abnormalities (eg, Familial Adenomatous Polyposis, Fanconi-Bickel syndrome)
- Severe, known dysmotility syndrome such as pseudo-obstruction or persistent, severe, active gastroschisis-related dysmotility; that is the primary contributing factor to feeding intolerance and inability to reduce parenteral support, prior to screening. Dysmotility is defined as severe if it is expected to limit the advancement of enteral feeding.
- Evidence of clinically significant obstruction on the most recent upper GI series done within 6 months prior to screening.
- Major GI surgical intervention including significant intestinal resection within 3 months prior to screening (insertion of feeding tube, anastomotic ulcer repair, minor intestinal resections <=10 centimeter (cm), or endoscopic procedure is allowed)
- Unstable cardiac disease or congenital heart disease or cyanotic disease, with the exception of participants who had undergone ventricular or atrial septal defect repair, and patent ductus arteriosus (PDA) ligation
- History of cancer or clinically significant lymphoproliferative disease, not including resected cutaneous basal or squamous cell carcinoma, or in situ nonaggressive and surgically resected cancer. Participants with known cancer predisposition syndrome, such as juvenile polyposis or Beckwith-Wiedemann syndrome, or first degree relative with early onset of GI cancer (including hepatobiliary and pancreatic cancer) will also be excluded.
- Pregnant or lactating female participants
- Participation in a clinical study using an experimental drug (other than glutamine or Omegaven) within 3 months or 5.5 half-lives of the experimental drug, whichever is longer, prior to screening and for the duration of the study
- Previous use of teduglutide or native/synthetic GLP-2
- Previous use of glucagon-like peptide-1 analog or human growth hormone within 3 months prior to screening
- Previous use of octreotide or dipeptidyl peptidase-4 (DPP-4) inhibitors within 3 months prior to screening
- Participants with active Crohn's disease who had been treated with biological therapy (eg, antitumor necrosis factor [anti-TNF]) within the 6 months prior to the screening visit
- Participants with inflammatory bowel disease (IBD) who require chronic systemic immunosuppressant therapy that had been introduced or changed during the 3 months prior to screening
- More than 3 serious complications of SBS (eg, documented infection-related catheter sepsis, clots, bowel obstruction, severe water-electrolyte disturbances) within 3 months prior to the screening visit
- A serious complication that affects parenteral support requirements within 1 month prior to or during screening, excluding uncomplicated treatment of bacteremia, central line replacement/repair, or issues of similar magnitude in an otherwise stable participant
- Body weight < 5 kilogram (kg) at screening and baseline visits
- Signs of active, severe, or unstable clinically significant hepatic impairment during the screening period:
For infants 4 to <12 months corrected gestational age at least 2 of any of the following parameters:
- International normalized ratio (INR) >1.5 not corrected with parenteral vitamin K
- Platelet count <100×10^3/ (microliters)mcL due to portal hypertension
- Presence of clinically significant gastric or esophageal varices
- Documented cirrhosis
- Persistent cholestasis defined as conjugated bilirubin >4 milligram per deciliter (mg/dL) (>68 micromoles per liter [mcmol/L]) over a 2 week period
For children 1 to 15 years of age:
Total bilirubin >= 2x upper limit of normal (ULN)
Aspartate aminotransferase (AST) >= 7x ULN
Alanine aminotransferase (ALT) >= 7x ULN
- Signs of known continuous active or unstable, clinically significant renal dysfunction shown by results of an estimated glomerular filtration rate below 50 milliliter per minute (mL/min)/1.73 meter (m)^2
- Parent(s)/guardian(s) and/or participants who are not capable of understanding or not willing to adhere to the study visit schedule and other protocol requirements
- Unstable, clinically significant, active, untreated pancreatic or biliary disease
- Any condition, disease, illness, or circumstance that in the investigator's opinion puts the participant at any undue risk, prevents completion of the study, or interferes with analysis of the study results.