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| Name | Class |
|---|---|
| Shenzhen Children's Hospital | OTHER_GOV |
| General Hospital of Ningxia Medical University | OTHER |
| Xijing Hospital | OTHER |
| Second Affiliated Hospital of Wenzhou Medical University |
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The aim of this study is to explore the relationship between brain MRI-metrics and hand function observed in children with cerebral palsy (CP),compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictor of clinical improvement following therapy in children with CP.
Cerebral palsy (CP) is the commonest cause of neurological disability in children. The upper limbs are often affected, with significant hand involvement from an early age.There are various methods of treatment for CP children with hand function disability. However, there is a lack of effective methods to predict the prognosis.
This prospective cohort study will include children with occupational therapy (OT) or OT plus acupuncture and massage methods. Children with CP will be evaluated in terms of upper limb motor function using the manual ability classification system (MACS), fine motor function measure (FMFM). The Brain injuries of Children will be evaluated by MRI.
The aim of this study is to explore the relationship between brain MRI-metrics and hand function, compared between baseline and the third month, and thus determine the early MRI-based neuroimaging predictors of clinical improvements following therapy in children with CP.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Occupational therapy group | Placebo Comparator | The children worked with an occupational therapist for 4 hours a day for 5 days per week (totaling 40 hours) and initially concentrated on unilateral activities with the hemiplegic hand,and added bilateral activities during the second week. |
|
| Occupational therapy puls acupuncture and massage methods | Active Comparator | The patients receive occupational therapy puls acupuncture and massage methods. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Occupational therapy | Behavioral |
| ||
| Measure | Description | Time Frame |
|---|---|---|
| Fine motor function measure (scores) | It is acquired at baseline. | Baseline |
| Fine motor function measure (scores) | It is acquired at 3 months later following therapy. | The 3rd month |
| Measure | Description | Time Frame |
|---|---|---|
| Gross motor function measure and classification system (scores) | It is acquired at baseline.The system is a 5 level clinical classification system that describes the gross motor function of people with cerebral palsy on the basis of self-initiated movement abilities. | Baseline |
| Gross motor function measure and classification system (scores) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jian Yang, Ph.D.,M.D. | Contact | +8618991232396 | cjr.yangjian@vip.163.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| First Affiliated Hospital of Xi'an Jiaotong University | Recruiting | Xi'an | Shaanxi | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31559169 | Derived | Liu H, Jiang H, Wang X, Zheng J, Zhao H, Cheng Y, Tao X, Wang M, Liu C, Huang T, Wu L, Jin C, Li X, Wang H, Yang J. Treatment response prediction of rehabilitation program in children with cerebral palsy using radiomics strategy: protocol for a multicenter prospective cohort study in west China. Quant Imaging Med Surg. 2019 Aug;9(8):1402-1412. doi: 10.21037/qims.2019.04.04. |
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| OTHER |
| Shaanxi Provincial People's Hospital | OTHER |
| Baoji Central Hospital | OTHER |
| Children's Hospital of Fudan University | OTHER |
| Hainan People's Hospital | OTHER |
| Zunyi Medical College | OTHER |
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| Occupational therapy puls acupuncture and massage methods |
| Other |
|
It is acquired at 3 months later following therapy. |
| The 3rd month |
| ID | Term |
|---|---|
| D020208 | Brain Injury, Chronic |
| D002547 | Cerebral Palsy |
| ID | Term |
|---|---|
| D001925 | Brain Damage, Chronic |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D001930 | Brain Injuries |
| D006259 | Craniocerebral Trauma |
| D020196 | Trauma, Nervous System |
| D002908 | Chronic Disease |
| D020969 | Disease Attributes |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D014947 | Wounds and Injuries |
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| ID | Term |
|---|---|
| D009788 | Occupational Therapy |
| ID | Term |
|---|---|
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
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