The aim of this study is to investigate the potential value of a novel imaging technique (hyperpolarized 129Xe lung imaging) in the diagnosis and assessment of lung disease in patients with COPD and IPF.

General Inclusion criteria

• Male or Female aged over 18 years.
• Capacity to give informed consent
• Normal blood pressure (systolic BP > 100 mmHg and diastolic BP > 70 mmHg)
• Resting heart rate > 50 bpm
• For women, negative urinary β-hCG at the screening and subsequent visits
• Subject able to hold breath for 10 seconds
• Subject able to fit into 129Xe chest coil used for MRI
• Subject able to understand the requirements of the study and to cooperate with the study procedures

Inclusion criteria

HEALTHY VOLUNTEERS

• No significant respiratory disease within the last year

PATIENTS

COPD

• Evidence of airflow obstruction (FEV/FVC <0.7) and FEV1 <80% predicted post bronchodilator
• Minimum FVC 1.5L

Exclusion criteria

HEALTHY VOLUNTEERS

• Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
• Acute respiratory illness within 30 days of MRI
• Subject has received an IMP (not including hyperpolarized 129Xe) within 30 days of MRI and administration of 129Xe deemed inappropriate in context of other study
• Subject deemed unlikely to comply with instructions during imaging
• Do not meet the inclusion criteria above
• Subject not deemed fit enough to tolerate procedure
• Subject deemed unsuitable by clinical investigator for other reasons

PATIENTS

• Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
• Acute respiratory illness within 30 days of MRI
• Subject has received an IMP (not including hyperpolarized 129Xe) within 30 days of MRI and administration of 129Xe deemed inappropriate in context of other study
• Subject deemed unlikely to comply with instructions during imaging
• Do not meet the inclusion criteria above
• Subject not deemed fit enough to tolerate procedure
• Subject deemed unsuitable by clinical investigator for other reasons

Healthy Volunteers, COPD