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| ID | Type | Description | Link |
|---|---|---|---|
| 2012-A00796-37 | Registry Identifier | IDRCB |
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In human, the physiology of gait and balance is not clearly established. By using functional imaging and electrophysiological techniques, various brain regions from the cortex to the midbrain area, including the cerebellum, have been identified as involved in such control. The specific role of these structures in both the capacity to go forward (locomotion) and stand upright (balance), but also in the different phases of the gait initiation process, are not known, however. In this study,the investigators aimed to assess the specific role of both the supplementary motor area (SMA) and the cerebellum in postural control during the initiation of gait. For this purpose, the investigators plan to study the gait initiation in 20 healthy subjects before and after functional inactivation (using inhibitory repetitive transcranial magnetic stimulation, rTMS) of the cerebellum or SMA. Biomechanical, kinematic and electromyographic parameters of the gait initiation will be recorded using a force platform, reflective markers with infrared cameras (VICON system) and lower limbs surface EMG electrodes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| transcranial magnetic stimulation | Sham Comparator | sham transcranial magnetic stimulation |
|
| supplementary motor area stimulation | Experimental | supplementary motor area transcranial magnetic stimulation |
|
| cerebellar stimulation | Experimental | cerebellar transcranial magnetic stimulation |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial magnetic stimulation | Other | comparison of different conditions of transcranial magnetic stimulation |
|
| Measure | Description | Time Frame |
|---|---|---|
| postural control during gait initiation | braking capacity | change between baseline and 5 minutes after transcranial magnetic stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| duration of anticipatory postural adjustments | duration | change between baseline and 5 minutes after transcranial magnetic stimulation |
| Measure | Description | Time Frame |
|---|---|---|
| centre of foot pressure displacement during postural adjustments | centre of foot pressure displacement measured by force platform | change between baseline and 5 minutes after transcranial magnetic stimulation |
| step length |
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Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Marie-Laure Welter, MD, PhD | APHP | Principal Investigator |
| Sabine Meunier, MD, PhD | Institut National de la Santé Et de la Recherche Médicale, France | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| M.L.Welter | Paris | 75013 | France |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 28673716 | Result | Richard A, Van Hamme A, Drevelle X, Golmard JL, Meunier S, Welter ML. Contribution of the supplementary motor area and the cerebellum to the anticipatory postural adjustments and execution phases of human gait initiation. Neuroscience. 2017 Sep 1;358:181-189. doi: 10.1016/j.neuroscience.2017.06.047. Epub 2017 Jul 1. |
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| ID | Term |
|---|---|
| D050781 | Transcranial Magnetic Stimulation |
| ID | Term |
|---|---|
| D055909 | Magnetic Field Therapy |
| D013812 | Therapeutics |
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step length
| change between baseline and 5 minutes after transcranial magnetic stimulation |
| step velocity | step velocity | change between baseline and 5 minutes after transcranial magnetic stimulation |
| duration of electromyographic activity of the tibialis anterior muscles | change between baseline and 5 minutes after magnetic transcranial stimulation |