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| Name | Class |
|---|---|
| PLA General Hospital | UNKNOWN |
| Second Xiangya Hospital of Central South University | OTHER |
| Xiangya No.1 Hospital of Central South University | UNKNOWN |
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ARDS is a critical respiratory disease caused by endogenous and exogenous factors. The mortality of ARDS varies from 30 to 70%. In 2012, a new international diagnostic criterion has been put forward. Yet, its feasibility, reliability and validity need to be tested. Meanwhile, the correlation of different severity and prognosis remains unclear. As so far, the epidemiological information about ARDS in China is lacking.
Investigators plan to conduct a multi-center observational study（real-life study） to investigate the risk factors, morbidity, management and prognosis of ARDS in China, in order to facilitate standardization of diagnosis and management of ARDS and provide basic data and idea for further clinical intervention studies.
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| Measure | Description | Time Frame |
|---|---|---|
| Mortality | the 28days mortality after the diagnosis of ARDS | 28days |
| Measure | Description | Time Frame |
|---|---|---|
| Length of ICU stay | The days between admission to intensive care unit(ICU) and discharge from ICU. | 90 days |
| Ventilation free days | The days between successful weaning from mechanical ventilation and day 28 after study enrollment. |
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Inclusion Criteria:
Exclusion Criteria:
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This research plans to enroll 400 hospitalized patients (≥ 18 years old with main diagnosis as ARDS). Sample size estimation is based on estimated mortality of ARDS hospitalized patients (~5%). Study patients will be recruited from 20 hospitals across China,each hospital will recruit 20 patients. Hospital selection follows a multi-stage sampling strategy.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Huang Xu | Contact | 8613641345816 | huangxu1122@sina.com | |
| Zhan Qingyuan | Contact | 8613911785957 | dr.zhanqy@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| China - Japan Friendship Hospital | Recruiting | Beijing | Beijing Municipality | 100029 | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41167619 | Derived | Yang H, Xia J, Huang X, Bai Y, Jin D, Nouraie SM, McVerry BJ, Morris A, Kitsios GD, Wang C, Zhan Q. Generalisability of ARDS biological subphenotype models in Asians: an international, multicentre, prospective biomarker study. Thorax. 2026 Feb 16;81(3):257-266. doi: 10.1136/thorax-2025-223421. | |
| 32819400 | Derived |
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| ID | Term |
|---|---|
| D012128 | Respiratory Distress Syndrome |
| ID | Term |
|---|---|
| D008171 | Lung Diseases |
| D012140 | Respiratory Tract Diseases |
| D012120 | Respiration Disorders |
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| The Second Affiliated Hospital of Chongqing Medical University |
| OTHER |
| Beijing Chao Yang Hospital | OTHER |
| First Affiliated Hospital of Xinjiang Medical University | OTHER |
| First Hospital of China Medical University | OTHER |
| Nanjing General Hospital | UNKNOWN |
| Peking University First Hospital | OTHER |
| Third Hospital Affiliated to Neimenggu Medical University | UNKNOWN |
| The Second Hospital of Hebei Medical University | OTHER |
| Qilu Hospital of Shandong University | OTHER |
| Ruijin Hospital | OTHER |
| Beijing Hospital | OTHER_GOV |
| Peking Union Medical College Hospital | OTHER |
| No.3 Hospital of Peking University | UNKNOWN |
| Fuxing Hospital | UNKNOWN |
| Fujian Provincial Hospital | OTHER |
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| 28 days |
| Incidence of ARDS | The total number of acute respiratory distress syndrome(ARDS)patients in 2 years. | 2 years |
| Severity of patients | Number of patients in each grade of severities according to Berlin definition: the number of mild, moderate and severe acute respiratory distress syndrome(ARDS) patients will be recorded. | 2 years |
| Adverse events related to treatment | Number of patients with adverse events, include biotrauma, worsen of hemodynamics, hospital-acquired infection, patient-ventilator asynchrony, gastric distention, aspiration etc. | 90 days |
| Number of patients using adjuvant drugs | Adjuvant drugs refer to corticosteroid, sedative, analgesic and non depolarizing muscle relaxant. | 28 days |
| Number of patients with high risk factors | High risk factors for acute respiratory distress syndrome(ARDS), including endogenous factors as pneumonia, aspiration, lung contusion and drowning; the exogenous factors as extrapulmonary trauma, extra pulmonary sepsis , hypovolemic shock, pancreatitis, severe burning, drug overdose, blood transfusion，eclampsia etc. | 1 week |
| Number of patients with conventional respiratory support techniques | Conventional respiratory support techniques include noninvasive positive pressure ventilation(NPPV), invasive positive pressure ventilation(include volume-controlled ventilation and pressure-controlled ventilation) . | 28 days |
| Number of patients with unconventional respiratory support techniques | Unconventional respiratory support techniques include recruitment maneuver(RM), prone position ventilation(PPV), high-frequency oscillatory ventilation(HFOV) ,extracorporeal membrane oxygenation(ECMO) and extracorporeal CO2 removal(ECCO2R) | 28 days |
| Number of patients with impaired lung function | The number patients with impaired lung function 90 days and 1 year after diagnosis of acute respiratory distress syndrome(ARDS). | 90 days, 1 year |
| Number of patients with abnormal lung CT | The number patients with abnormal lung CT 90 days and 1 year after diagnosis of acute respiratory distress syndrome(ARDS). | 90 days, 1 year |
| Huang X, Zhang R, Fan G, Wu D, Lu H, Wang D, Deng W, Sun T, Xing L, Liu S, Wang S, Cai Y, Tian Y, Zhang Y, Xia J, Zhan Q; CHARDSnet group. Incidence and outcomes of acute respiratory distress syndrome in intensive care units of mainland China: a multicentre prospective longitudinal study. Crit Care. 2020 Aug 20;24(1):515. doi: 10.1186/s13054-020-03112-0. |