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| ID | Type | Description | Link |
|---|---|---|---|
| 1R01AR063713-01A1 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | NIH |
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The purpose of this study is to examine deficits in activation and motor patterns, as well as central drive in patients with rotator cuff tendinopathy. There are three specific aims: (1) determine the effect of acute pain relief on rotator cuff muscle activation in patients with rotator cuff tendinopathy, (2) determine the effect of exercise on rotator cuff muscle activation in patients with rotator cuff tendinopathy, and (3) compare rotator cuff muscle activation between patients with rotator cuff tendinopathy and healthy controls.
The long-term goal of our research agenda is to identify the mechanisms associated with rotator cuff tendinopathy (impingement syndrome) and subsequently evaluate novel treatment strategies that address these mechanisms. The objectives of this application are to study the muscle patterns in patients with rotator cuff tendinopathy as well as the effects of both pain and exercise on these patterns. Our first hypothesis is that pain relief from a shoulder injection will result in increased rotator cuff activity. Our second hypothesis is that patients with tendinopathy will demonstrate improved rotator cuff muscle activity following a six-week exercise program and that this improvement will be higher in patients that respond favorably to treatment. Our final hypothesis is that patients with cuff tendinopathy will show decreased rotator cuff activity compared to healthy subjects. The investigators plan on addressing these hypotheses using several novel techniques for muscle activity assessment.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients | Experimental | Subjects with shoulder tendinopathy who will undergo both a subacromial injection and physical therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Subacromial injection | Procedure | A subacromial injection consisting up 6 cc 0.5% Marcaine with Epinephrine and 1 cc DepoMedrol will be administered. |
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| Measure | Description | Time Frame |
|---|---|---|
| Rotator cuff activation after subacromial injection and exercise intervention, difference in rotator cuff voluntary activation between subjects and controls | Assessed using voluntary activation | 6 weeks |
| Rotator cuff activation after subacromial injection and exercise intervention, difference in specific rotator cuff muscle activation between subjects and controls | Assessed using electromyography (EMG) | 6 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Rotator cuff voluntary activation after subacromial injection | Assessed using voluntary activation | 2 hours |
| Rotator cuff muscle activation after subacromial injection | Assessed using EMG |
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Patient Inclusion Criteria:
Patient Exclusion Criteria:
Control Inclusion Criteria:
Control Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Andrew R Karduna, PhD | University of Oregon | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Oregon | Eugene | Oregon | 97403 | United States |
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| ID | Term |
|---|---|
| D059787 | Acute Pain |
| D001284 | Atrophy |
| D014947 | Wounds and Injuries |
| D018908 | Muscle Weakness |
| D010146 | Pain |
| D020069 | Shoulder Pain |
| D013577 | Syndrome |
| D052256 | Tendinopathy |
| D009043 | Motor Activity |
| D010342 | Patient Acceptance of Health Care |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D020763 | Pathological Conditions, Anatomical |
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| ID | Term |
|---|---|
| D026741 | Physical Therapy Modalities |
| ID | Term |
|---|---|
| D013812 | Therapeutics |
| D012046 | Rehabilitation |
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| Physical Therapy | Other | A standardized six-week exercise protocol supervised by a physical therapist |
|
| 2 hours |
| Rotator cuff voluntary activation correlations with pain levels | Assessed using voluntary activation relative to self-reported pain level | 2 hours |
| Rotator cuff activation correlations with pain levels | Assessed using EMG relative to self-reported pain level | 2 hours |
| Rotator cuff voluntary activation after 6-week exercise intervention and subacromial injection | Assessed using voluntary activation | 6 weeks |
| Rotator cuff muscle activation after 6-week exercise intervention and subacromial injection | Assessed using EMG | 6 weeks |
| Rotator cuff voluntary activation correlation with improvements in pain relief | Assessed using voluntary activation relative to self-reported pain relief | 6 weeks |
| Rotator cuff voluntary activation correlation with improvements in clinical outcome measures | Assessed using voluntary activation relative to changes in questionnaire scores | 6 weeks |
| Rotator cuff muscle activation correlation with improvements in pain relief | Assessed using EMG relative to self-reported pain relief | 6 weeks |
| Rotator cuff muscle activation correlation with improvements in clinical outcome measures | Assessed using EMG relative to changes in questionnaire scores | 6 weeks |
| Prior to treatment, rotator cuff voluntary activation in patients relative to healthy controls | Assessed using voluntary activation | 6 weeks |
| Prior to treatment, rotator cuff muscle activation in patients relative to healthy controls | Assessed using EMG | 6 weeks |
| After both a subacromial injection and a six-week exercise program, differences in rotator cuff voluntary activation between patients and healthy controls | Assessed using voluntary activation | 6 weeks |
| After both a subacromial injection and a six-week exercise program, differences in rotator cuff muscle activation between patients and healthy controls | Assessed using EMG | 6 weeks |
| D009135 | Muscular Diseases |
| D009140 | Musculoskeletal Diseases |
| D020879 | Neuromuscular Manifestations |
| D009422 | Nervous System Diseases |
| D010335 | Pathologic Processes |
| D018771 | Arthralgia |
| D007592 | Joint Diseases |
| D004194 | Disease |
| D013708 | Tendon Injuries |
| D001519 | Behavior |
| D000074822 | Treatment Adherence and Compliance |
| D015438 | Health Behavior |