Therapy of Obesity and Diabetes Mellitus Type 2

Evaluation of a Structured Weight-loss Program for Therapy of Obesity and Diabetes Mellitus Type 2

To evaluate a standardized weight-loss program as treatment option for obesity and type 2 diabetes, changes in body composition and metabolic control are investigated in obese patients with diabetes.

Men and women with obesity and diabetes mellitus type 2 are invited to join a standardized weight-loss program (six weeks of formula diet, followed by the reintroduction of regular food with gradually increasing energy intake over nine weeks) for a duration of 15 weeks. All subjects undergo bioelectrical impedance analyses to investigate body composition and magnet resonance imaging to measure fat mass and fat fractions of abdominal organs, at three time points: first before the program, then at the end of the six weeks of formula diet and finally, at the end of the program after 15 weeks. Laboratory data are measured before and after the program.

Inclusion Criteria:

• known type 2 diabetes
• body-mass-index between 27 and 45 kg/m²

Exclusion Criteria:

• treatment with incretin mimetic drugs < 3 month
• pregnancy
• immobilization
• severe heart, liver or renal failure
• dementia
• eating disorder
• alcoholism