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Follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI_MED-project (Greifswald Approach to Individualized Medicine). Standardized protocols will be used for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. Comparisons with the general background population will be performed.
5-year follow-up of two hospital-based patient cohorts (heart failure, metabolic comorbidities in CVD), recruited at baseline by the GANI_MED-project (Greifswald Approach to Individualized Medicine). Subjects will be comprehensively phenotypes using standardized protocols for the assessment of medical history, laboratory biomarkers, and the collection of various biosamples for bio-banking purposes. A multi-omics based biomarker assessment including genome-wide genotyping, transcriptome, metabolome, and proteome analyses complements the multi-level approach of GANI_MED. Comparisons with the general background population as characterized by the Study of Health in Pomerania (SHIP) will be performed.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Heart Failure | Patients with chronic heart failure and with/without reduced left ventricular ejection fraction (EF) at baseline (HFrEF, HFmrEF, HFpEF) |
| |
| Cardiometabolic risk | Patients with cardiovascular diseases and metabolic risk factors at baseline |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| no intervention, only observational | Other | no intervention, only observational |
|
| Measure | Description | Time Frame |
|---|---|---|
| Cardiovascular events | Hospitalization (HF based. all-cause), myocardial infarction | 1-year follow-ups |
| Measure | Description | Time Frame |
|---|---|---|
| VO2peak | Exercise capacity by CPET | 1-year follow-ups |
| QOL | Quality of life by questionnaire (Minnesota Living with heart failure questionnaire) |
| Measure | Description | Time Frame |
|---|---|---|
| PWA | pulse wave analysis parameters by Vascular Explorer device (neverdis GmbH, Germany) | 1-year follow-ups |
Inclusion Criteria:
Exclusion Criteria:
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All patients included into the baseline examinations of the two cohorts
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Marcus Dörr, MD | Contact | +49383486 | 80500 | mdoerr@uni-greifswald.de |
| Stephan B Felix, MD | Contact | +49383486 | 80500 | felix@uni-greifswald.de |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Department of Internal Medicine B, University Medicine Greifswald | Recruiting | Greifswald | Mecklenburg-Vorpommern | 17475 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 24886498 | Background | Grabe HJ, Assel H, Bahls T, Dorr M, Endlich K, Endlich N, Erdmann P, Ewert R, Felix SB, Fiene B, Fischer T, Flessa S, Friedrich N, Gadebusch-Bondio M, Salazar MG, Hammer E, Haring R, Havemann C, Hecker M, Hoffmann W, Holtfreter B, Kacprowski T, Klein K, Kocher T, Kock H, Krafczyk J, Kuhn J, Langanke M, Lendeckel U, Lerch MM, Lieb W, Lorbeer R, Mayerle J, Meissner K, zu Schwabedissen HM, Nauck M, Ott K, Rathmann W, Rettig R, Richardt C, Salje K, Schminke U, Schulz A, Schwab M, Siegmund W, Stracke S, Suhre K, Ueffing M, Ungerer S, Volker U, Volzke H, Wallaschofski H, Werner V, Zygmunt MT, Kroemer HK. Cohort profile: Greifswald approach to individualized medicine (GANI_MED). J Transl Med. 2014 May 23;12:144. doi: 10.1186/1479-5876-12-144. |
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| ID | Term |
|---|---|
| D024821 | Metabolic Syndrome |
| D006333 | Heart Failure |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| ID | Term |
|---|---|
| D007333 | Insulin Resistance |
| D006946 | Hyperinsulinism |
| D044882 | Glucose Metabolism Disorders |
| D008659 | Metabolic Diseases |
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blood, urine
| 1-year follow-ups |
| 6MW | 6 minute walk test distance | 1-year follow-ups |
| LVEF | Left ventricular ejection fraction by echo at time of follow-up | 1-year follow-ups |
| D009750 |
| Nutritional and Metabolic Diseases |