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The purpose of this study is to develop the electronic management platform for children with epilepsy, establish large data of Chinese children with epilepsy and explore its biological etiology.
The establishment of the electronic management platform for children with epilepsy and large data of epilepsy in Chinese children as well as the epidemiological study its biological etiology.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Genetic | patients with Gene detection (+) | ||
| Metabolism | patients with Metabolic disturbance | ||
| Immune | patients with Immunological marker and Immunotherapy (+) | ||
| infection | patients with the Infection of central nervous system | ||
| structure | patients with abnormal image of brain | ||
| unknown | patients not found any reason |
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| Measure | Description | Time Frame |
|---|---|---|
| The data of over 10 thousand childhood epilepsy patients in China | To develop a public platform for electronic analysis and management of children epilepsy to doctors and patients in China | 26 month after developing a public platform for electronic analysis and management |
| Measure | Description | Time Frame |
|---|---|---|
| Incidence of several different causes of children epilepsy in China | A surveillance mechanism will be developed to identify and recruit children with epilepsy from the public platform for electronic analysis management of children epilepsy for doctors and patients | up to 26 months |
| Measure | Description | Time Frame |
|---|---|---|
| gene mutation | To detect the mutation and characterize the genetic architecture and risk variants of epilepsy using genomic methods | 30 days after receipt of DNA sample |
| immune factors | To test Inflammatory factors, Autoimmune antibodies , Immunoglobulin |
Inclusion Criteria:
Exclusion Criteria:
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0-14 years old epilepsy patients in China
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ling Li | Shanghai | 200092 | China |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 26659723 | Background | Sauro KM, Wiebe S, Dunkley C, Janszky J, Kumlien E, Moshe S, Nakasato N, Pedley TA, Perucca E, Senties H, Thomas SV, Wang Y, Wilmshurst J, Jette N. The current state of epilepsy guidelines: A systematic review. Epilepsia. 2016 Jan;57(1):13-23. doi: 10.1111/epi.13273. Epub 2015 Dec 10. | |
| 27719996 | Result | Singh A, Trevick S. The Epidemiology of Global Epilepsy. Neurol Clin. 2016 Nov;34(4):837-847. doi: 10.1016/j.ncl.2016.06.015. |
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| ID | Term |
|---|---|
| D004827 | Epilepsy |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| 7days after receipt of blood sample or/and cerebrospinal fluid |
| metabolic factors | To test tandem mass spectrometry and enzyme | 7days after receipt of blood sample or/and urine |
| structural factors | To scan head MRI | 5ays after patients see doctor |
| Infection factors | To test various pathogen | 7days after receipt of blood sample, urine and cerebrospinal fluid |
| 23329469 | Result | Lua PL, Neni WS. Health-related quality of life improvement via telemedicine for epilepsy: printed versus SMS-based education intervention. Qual Life Res. 2013 Oct;22(8):2123-32. doi: 10.1007/s11136-013-0352-6. Epub 2013 Jan 18. |
| 23962794 | Result | Coles LD, Patterson EE, Sheffield WD, Mavoori J, Higgins J, Michael B, Leyde K, Cloyd JC, Litt B, Vite C, Worrell GA. Feasibility study of a caregiver seizure alert system in canine epilepsy. Epilepsy Res. 2013 Oct;106(3):456-60. doi: 10.1016/j.eplepsyres.2013.06.007. Epub 2013 Aug 18. |
| 25393786 | Result | Tzallas AT, Tsipouras MG, Rigas G, Tsalikakis DG, Karvounis EC, Chondrogiorgi M, Psomadellis F, Cancela J, Pastorino M, Waldmeyer MT, Konitsiotis S, Fotiadis DI. PERFORM: a system for monitoring, assessment and management of patients with Parkinson's disease. Sensors (Basel). 2014 Nov 11;14(11):21329-57. doi: 10.3390/s141121329. |
| 21921003 | Result | Larner AJ. Teleneurology: an overview of current status. Pract Neurol. 2011 Oct;11(5):283-8. doi: 10.1136/practneurol-2011-000090. |
| 26022171 | Result | Hani AJ, Mikati HM, Mikati MA. Genetics of pediatric epilepsy. Pediatr Clin North Am. 2015 Jun;62(3):703-22. doi: 10.1016/j.pcl.2015.03.013. |
| 25042079 | Result | Bearden D, Strong A, Ehnot J, DiGiovine M, Dlugos D, Goldberg EM. Targeted treatment of migrating partial seizures of infancy with quinidine. Ann Neurol. 2014 Sep;76(3):457-61. doi: 10.1002/ana.24229. Epub 2014 Jul 26. |
| 26886357 | Result | Wright S, Vincent A. Progress in autoimmune epileptic encephalitis. Curr Opin Neurol. 2016 Apr;29(2):151-7. doi: 10.1097/WCO.0000000000000304. |
| 26821542 | Result | Patel J, Mercimek-Mahmutoglu S. Epileptic Encephalopathy in Childhood: A Stepwise Approach for Identification of Underlying Genetic Causes. Indian J Pediatr. 2016 Oct;83(10):1164-74. doi: 10.1007/s12098-015-1979-9. Epub 2016 Jan 29. |
| 27186225 | Result | Kim EH, Ko TS. Cognitive impairment in childhood onset epilepsy: up-to-date information about its causes. Korean J Pediatr. 2016 Apr;59(4):155-64. doi: 10.3345/kjp.2016.59.4.155. Epub 2016 Apr 30. |
| 26060903 | Result | Bonello M, Michael BD, Solomon T. Infective Causes of Epilepsy. Semin Neurol. 2015 Jun;35(3):235-44. doi: 10.1055/s-0035-1552619. Epub 2015 Jun 10. |
| 40209515 | Derived | Zhang Z, Wu J, Xu D, Zhao S, Lian D, Zhang D, Li L. Clinical characteristics and immunotherapy efficacy in autoimmune-associated benign epilepsy with centrotemporal spikes: A prospective cohort study. J Neuroimmunol. 2025 Jul 15;404:578603. doi: 10.1016/j.jneuroim.2025.578603. Epub 2025 Apr 4. |
| 34939173 | Derived | Yin Y, Wu J, Wu S, Chen S, Cheng W, Li L, Wang H. Usefulness of brain FDG PET/CT imaging in pediatric patients with suspected autoimmune encephalitis from a prospective study. Eur J Nucl Med Mol Imaging. 2022 May;49(6):1918-1929. doi: 10.1007/s00259-021-05649-w. Epub 2021 Dec 23. |