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In this 3-year successive research plan, investigators will conduct a prehospital randomized controlled trial to address the following question: In adult patients with non-traumatic cause of out-of-hospital cardiac arrest resuscitated by emergency medical technician (paramedic level) in the prehospital setting, will receiving endotracheal tube intubation cause a better chance of sustained recovery of spontaneous circulation and other survival outcomes like neurologically favorable status, comparing to those who receiving supraglottic airway device.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| supraglottic airway (SGA) | Active Comparator | Adult patients with non-trauma causes of OHCA who are resuscitated by emergency medical technician paramedic (EMTP) in the prehospital setting and received airway management of supraglottic airway (SGA). |
|
| endotracheal intubation (ETI) | Active Comparator | Adult patients with non-trauma causes of OHCA who are resuscitated by emergency medical technician paramedic (EMTP) in the prehospital setting and received airway management of endotracheal intubation (ETI). |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| supraglottic airway (SGA) V.S. endotracheal intubation (ETI) | Device | already being described above |
|
| Measure | Description | Time Frame |
|---|---|---|
| survival to admission | Measurement of outcome by standard Utstein OHCA registry system in Taipei City | One month after event |
| Measure | Description | Time Frame |
|---|---|---|
| any ROSC | Measurement of outcome by standard Utstein OHCA registry system in Taipei City | One month after event |
| survival to discharge | Measurement of outcome by standard Utstein OHCA registry system in Taipei City |
| Measure | Description | Time Frame |
|---|---|---|
| The rate of survival to discharge of OHCAs resuscitated by non-paramedic (airway device: all SGA) | Measurement of outcome by standard Utstein OHCA registry system in Taipei City | One month after event |
| The interaction between age and airway management |
Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wen-Chu Chiang, MD, PhD. | Contact | +886-2-23123456 | 62831 | drchiang.tw@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Wen-Chu Chiang, MD, PhD. | Emergency Dept, National Taiwan University Hospital | Principal Investigator |
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| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 35179588 | Derived | Lee AF, Chien YC, Lee BC, Yang WS, Wang YC, Lin HY, Huang EP, Chong KM, Sun JT, Huei-Ming M, Hsieh MJ, Chiang WC. Effect of Placement of a Supraglottic Airway Device vs Endotracheal Intubation on Return of Spontaneous Circulation in Adults With Out-of-Hospital Cardiac Arrest in Taipei, Taiwan: A Cluster Randomized Clinical Trial. JAMA Netw Open. 2022 Feb 1;5(2):e2148871. doi: 10.1001/jamanetworkopen.2021.48871. |
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| ID | Term |
|---|---|
| D058687 | Out-of-Hospital Cardiac Arrest |
| ID | Term |
|---|---|
| D006323 | Heart Arrest |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| One month after event |
| favorable neurologic outcome | Favorable neurologic outcome was defined by CPC (cerebral performance category) 1 and 2. Measurement of outcome by standard Utstein OHCA registry system in Taipei City | One month after event |
Deciphering interactions in logistic regression model with variables of standard Utstein OHCA registry system in Taipei City
| One month after event |
| The interaction between bystander CPR and airway management | Deciphering interactions in logistic regression model with variables of standard Utstein OHCA registry system in Taipei City | One month after event |
| The interaction between shockable rhythms and airway management | Deciphering interactions in logistic regression model with variables of standard Utstein OHCA registry system in Taipei City | One month after event |