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| Name | Class |
|---|---|
| State Administration of Traditional Chinese Medicine of the People's Republic of China | OTHER_GOV |
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This study evaluate the effects of acupuncture method on the recurrence of ischemic stroke patients.Half of participants will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. While the other half will receive 1 antihypertensive medication and basic treatments for ischemic stroke.
Under recuiting 480 patients come from 5 hospitals in China.Eligible patients will be randomly assigned into 2 groups: treatment group and control group. The treatment group will receive "Huo Xue San Feng" acupuncture combining 1 antihypertensive medication on the routine ischemic stroke treatments' basis. The control group will receive 1 antihypertensive medication and basic treatments for ischemic stroke. "Huo Xue San Feng" acupuncture will be given six sessions weekly for the first 6 weeks and three times weekly for the next 6 weeks. A 9-month follow-up will thereafter be conducted. Antihypertensive medications will be adjusted based on BP levels.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Treatment Group | Experimental | Participants will recieve the therapy as follows: "Huo Xue San Feng" acupuncture method+Routine care for ischemic stroke+One type of antihypertensive medication. Intervention:Acupuncture(choosing the bilatral acupoint: Renying(ST9),Hegu(L14), Taichong(LR3),Quchi(LI11),Zusanli(ST36))+Drugs(one type of antihypertensive medicine) |
|
| Control Group | No Intervention | Participants recieve the therapy as follows:Routine care for ischemic stroke +One type of antihypertensive medication. Intervention:Acupuncture(choosing the acupoint: Neiguan(PC6),Renzhong(10), Sanyinjiao(SP6),Jiquan(HT1),Chize(LU5),Weizhong(BL40).)+Drugs(one type of antihypertensive medicine) |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| acupuncture | Device |
The time of therapy will consist of 6 times per week in Continuous treatment phase(1st-6th week after enrollment) and 3 times per week(once every other day) in Consolidation treatment phase(7th-tewlve week after enrollment) |
| Measure | Description | Time Frame |
|---|---|---|
| The Effects of Acupuncture on Reccurence of Ischemic Stroke | The effects of acupuncture on reccurence of ischemic stroke assessed by China's Guidelines of Diagnosis and Treatment of Acute Ischemic Stroke 2014 and China's Guidelines of Diagnosis and Treatment of Cerebral Hemorrhage 2014. | 1 year after enrollment |
| Measure | Description | Time Frame |
|---|---|---|
| 24-hour ambulatory blood pressure | the first day、6 weeks、12 weeks after enrollment | |
| Daily Blood Pressure by Electronic Sphygmomanometer | 1 year after enrollment | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| yuzheng Du | Contact | 13702088266 | drduyuzheng11@163.com |
| Name | Affiliation | Role |
|---|---|---|
| Xuemin Shi | The First Teaching Hospital of Tianjin University of TCM | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chongqing Traditional Chinese Medicine Hospital | Not yet recruiting | Chongqing | China |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41993641 | Derived | Liu W, Li B, Rong M, Li C, Zhao Q, Zhang L, Tan X, He Q, Ban H, Meng X, Gu W, Gao X, Ma F, Ou M, Shi X, Du Y. Effect of acupuncture on ischemic stroke patients with hypertension: a randomized clinical trail. Front Neurol. 2026 Apr 1;17:1717706. doi: 10.3389/fneur.2026.1717706. eCollection 2026. | |
| 28915826 | Derived |
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| ID | Term |
|---|---|
| D002544 | Cerebral Infarction |
| D006973 | Hypertension |
| ID | Term |
|---|---|
| D020520 | Brain Infarction |
| D002545 | Brain Ischemia |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
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| ID | Term |
|---|---|
| D015670 | Acupuncture Therapy |
| D004304 | Dosage Forms |
| ID | Term |
|---|---|
| D000529 | Complementary Therapies |
| D013812 | Therapeutics |
| D004364 | Pharmaceutical Preparations |
| D013678 | Technology, Pharmaceutical |
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|
|
| Antihypertensive Drug Stop/Resumption/Increasing Rate |
| 1 year after enrollment |
| Nitric Oxide(NO) | the first day、12 weeks,6 months after enrollment |
| Endothelin(ET) | the first day、12 weeks,6 months after enrollment |
| The Cardiac Color Doppler Ultrasonography | the first day、12 weeks after enrollment |
| Carotid Color Ultrasonography | the first day、12 weeks after enrollment |
| Brain Color Doppler Ultrasonography | the first day、12 weeks after enrollment |
| Lower Extremity Color Ultrasonography | the first day、12 weeks after enrollment |
| TCM syndrome score | the first day、6 weeks、12 weeks after enrollment |
| Short Form 36-item Health Survey (SF-36) | the first day、6 weeks、12 weeks after enrollment |
| National Institute of Health stroke scale (NIHSS)，as well as Barthel Index (BI) scale | the first day、12 weeks after enrollment |
| Essen stroke risk score (ESRS) | the first day、1 year after enrollment |
| All-caused Morality | 1 year after enrollment |
| Serum homocysteine（Hcy） | the first day、12 weeks,6 months after enrollment |
| Soluble CD40L（sCD40L） | the first day、12 weeks,6 months after enrollment |
| Copeptin | the first day、12 weeks,6 months after enrollment |
| MIANYANG Hospital of Traditional Chinese Medicine | Not yet recruiting | Mianyang | China |
|
| LONGHUA Hospital Shanghai University of Traditional Chinese Medicine | Not yet recruiting | Shanghai | China |
|
| Shenzhen Bao'an Traditional Chinese Medicine Hospital Group | Not yet recruiting | Shenzhen | China |
|
| First Teaching Hospital of Tianjin University of TCM | Recruiting | Tianjin | China |
|
| Du YZ, Gao XX, Wang CT, Zheng HZ, Lei Y, Wu MH, Shi XM, Ban HP, Gu WL, Meng XG, Wei MT, Hu CX. Acupuncture lowering blood pressure for secondary prevention of stroke: a study protocol for a multicenter randomized controlled trial. Trials. 2017 Sep 15;18(1):428. doi: 10.1186/s13063-017-2171-5. |
| D002493 |
| Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020521 | Stroke |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
| D007238 | Infarction |
| D007511 | Ischemia |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D009336 | Necrosis |
| D008919 | Investigative Techniques |