Use of Adipose Tissue Derived Mesenchymal Stem Cells for Knee Osteoarthrosis

Knee Osteoarthrosis (KOA) in Jordanian Patients: a Phase I Dose-finding Study Using Adipose Tissue Derived Mesenchymal Stem Cells (ATMSC) for Advanced Stage III and IV KOA

Adipose tissue derived Mesenchymal Stem cells (ATMSC) will be injected in patients diagnosed with Knee osteoarthrosis

Ten patients from both genders diagnosed with Knee osteoarthrosis, will be enrolled according to specific inclusion and exclusion criteria. These patients will be injected with Adipose Tissue derived Mesenchymal Stem Cells. Then, they are followed by clinical assessment, laboratory investigations as well as magnetic resonance imaging (MRI) of the injected knee.

Inclusion Criteria:

Severe KOA stage III or IV by Laurance & Kellgren staging as judged by Posterioranterior (PA) Xray of the knee joint.

Willing to participate by signing the informed consent

Exclusion Criteria:

• Sublaxation beyond 20 degrees of the bones of the knee joint
• Oral anticoagulants or heparin therapy
• Heart failure or arrhythmia
• Body Mass Index > 35
• Uncontrolled Diabetes Mellitus.
• Evidence of Infectious Diseases.
• Active infection
• Malignancy
• Pregnancy
• Anemia less than 11g/dl or thrombocytopenia less than 100,000 or leucopenia less than 3000.
• Unreliable patients
• Non-resident in Jordan