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The purpose of this study is to study the effects of intermittent whole-body hypoxic preconditioning on patients with carotid artery stenosis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Mild hypoxia preconditioning | Active Comparator | Patients will be treated with mild hypoxia (Note: The oxygen concentration decreased from 20% to 18%, and keeping at 18%) before surgery. |
|
| Sham preconditioning | Sham Comparator | Patients will be treated with sham preconditioning (oxygen concentration: 21％) before surgery. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Mild Hypoxia Preconditioning | Procedure | Patients will be treated with mild hypoxia ( Note: The oxygen concentration decreased from 20% to 18%, and keeping at 18%)×7 days，twice a day in the morning and in the afternoon before surgery. |
| Measure | Description | Time Frame |
|---|---|---|
| Respiratory rate | Before, during and 5 min after the intervention. | |
| Heart rate | Before, during and 5 min after the intervention. | |
| Systolic blood pressure | Before, during and 5 min after the intervention. | |
| Arterial blood oxygen saturation | Before, during and 5 min after the intervention. | |
| Hemoglobin content | On admission, and at the 1st day after surgery. | |
| Hypoxia inducible factor-1α | On admission, and at the 1st day after surgery. | |
| Erythropoietin | On admission, and at the 1st day after surgery. | |
| Vascular endothelial growth factor | On admission, and at the 1st day after surgery. | |
| Neuron-specific enolase | On admission, and at the 1st day after surgery. | |
| S100β protein | On admission, and at the 1st day after surgery. | |
| Brain-derived neurotrophic factor |
| Measure | Description | Time Frame |
|---|---|---|
| Serum aspartate transaminase | On admission, and at the 1st day after surgery. | |
| Serum alanine aminotransferase | On admission, and at the 1st day after surgery. | |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hua Yan, Doctor | Tianjin Huanhu Hospital | Study Chair |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Tianjin HuanHu Hospital | Tianjin | Tianjin Municipality | 300350 | China |
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| ID | Term |
|---|---|
| D016893 | Carotid Stenosis |
| ID | Term |
|---|---|
| D002340 | Carotid Artery Diseases |
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
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| Sham preconditioning | Procedure | Patients will be treated with sham preconditioning (oxygen concentration: 21％) ×7 days，twice a day in the morning and in the afternoon before surgery. |
|
| On admission, and at the 1st day after surgery. |
| Serum creatinine |
| On admission, and at the 1st day after surgery. |
| Blood urea nitrogen | On admission, and at the 1st day after surgery. |
| The incidence of adverse events | During the intervention. |
| Average length of hospital stay | Through study completion, an average of 3 months. |
| Postoperative complications | Through study completion, an average of 3 months. |
| D009422 | Nervous System Diseases |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |