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The aim of this study is to compare personality and social cognition changes, including emotion detection and self-awareness, and neuroanatomical correlates in patients, and how that affects the caregiver-patient relationship.
The purpose of this study is to understand social cognition changes in patients with Alzheimer's disease (AD), Parkinson's disease (PD), and Frontotemporal Lobar Degeneration (FTLD), which includes Progressive Supranuclear Palsy (PSP), Corticobasal Syndrome (CBS) and Frontotemporal Dementia (FTD - behavioural variant frontotemporal dementia, progressive non-fluent aphasia and semantic dementia), and the effect of these changes on the patients' relationship with their caregivers. In addition, the study aims to provide a greater clarity in the neuroanatomical correlates of social cognition in patients with FTLD, PD and AD.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Alzheimer's disease | Observational Study |
| |
| Parkinson's disease | Observational Study |
| |
| Frontotemporal Lobar Degeneration | Observational Study |
| |
| Healthy Controls | Observational Study |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Observational Study | Behavioral | This is an observational study. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Personality via the Interpersonal Adjectives Scales and differences between AD, PD, and FTLD | Assesses interpersonal aspects of personality | one time visit, through study completion of 3 years |
| Personality via the Behaviour Inhibition/Approach Scale (BIS/BAS) and differences between AD, PD, and FTLD | Assesses the behavioural approach system that regulates appetitive motives, in which the goal is to move toward something desired, and the behavioural avoidance (or inhibition) system that regulates aversive motives, in which the goal is to move away from something unpleasant | one time visit, through study completion of 3 years |
| Personality via the Big Five Inventory (BFI) and differences between AD, PD, and FTLD | Assesses the patient's Big Five dimensions (openness, conscientiousness, extraversion, agreeableness, and neuroticism) with respect to past and current behavior | one time visit, through study completion of 3 years |
| Social cognition via Social Norms Questionnaire and differences between AD, PD, and FTLD | Assesses the patient's understanding of culturally relevant social norms | one time visit, through study completion of 3 years |
| Social cognition via Interpersonal Reactivity Index (IRI) and differences between AD, PD, and FTLD | Assesses the patient's empathy or ability to share in another's mental and emotional experience | one time visit, through study completion of 3 years |
| Social cognition via Revised Self-Monitoring Scale (RSMS) and differences between AD, PD, and FTLD |
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Inclusion Criteria:
Patients:
Caregivers:
Exclusion Criteria:
Patients and Caregivers:
Patients:
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Patients with a diagnosis of Alzheimer's disease, Parkinson's disease or Frontotemporal Lobar Degeneration
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| Name | Affiliation | Role |
|---|---|---|
| Maria C Tartaglia, M.D. | Toronto Western Hospital, UHN; Tanz CRND | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Toronto Western Hospital, University Health Network | Toronto | Ontario | M5T 2S8 | Canada |
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| ID | Term |
|---|---|
| D000544 | Alzheimer Disease |
| D010300 | Parkinson Disease |
| D057174 | Frontotemporal Lobar Degeneration |
| ID | Term |
|---|---|
| D003704 | Dementia |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
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| ID | Term |
|---|---|
| D019370 | Observation |
| ID | Term |
|---|---|
| D008722 | Methods |
| D008919 | Investigative Techniques |
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Assesses the patient's sensitivity to the expressive behaviour of others and their ability to monitor their self-presentation
| one time visit, through study completion of 3 years |
| Social cognition via Social Behaviour Observer Checklist and differences between AD, PD, and FTLD | Assesses behaviors specific to behavioural variant Frontotemporal Dementia (bvFTD) and is helpful in differentiating bvFTD versus Alzheimer's disease. | one time visit, through study completion of 3 years |
| Neuropsychiatric Inventory (NPI) and differences between AD, PD, and FTLD | Assesses 12 neuropsychiatric disturbances commonly encountered in patients with dementia, including: delusions, hallucinations, agitation, dysphoria, anxiety, apathy, irritability, euphoria, disinhibition, aberrant motor behaviour, night-time behaviour disturbances, and appetite and eating abnormalities | one time visit, through study completion of 3 years |
| Clinical Dementia Rating Scale (CDR) and differences between AD, PD, and FTLD | Assesses 8 domains of global dementia, including: memory, orientation, judgment/problem solving, community affairs, home and hobbies, personal care, behavioural comportment and personality, and language | one time visit, through study completion of 3 years |
| Functional Activities Questionnaire (FAQ) and differences between AD, PD, and FTLD | Assesses functional capacity in older adults | one time visit, through study completion of 3 years |
| Behavioural Tests composite score and differences between AD, PD, and FTLD | Orientation, Digit span backward and forward, Naming, Modified trails, Benson figure copy, Cerad, Clock draw | one time visit, through study completion of 3 years |
| Emotion Evaluation Task (EET) portion of The Awareness of Social Inference Test and differences between AD, PD, and FTLD | Assesses the recognition of six basic emotions commonly recognized across cultures (happiness, sadness, anger, surprise, disgust, fear) as well as a seventh "neutral" emotion. The emotions are presented via video vignettes. After viewing each scene, the patient will be asked to choose the emotion represented from a list of seven emotional categories. The caregiver will complete the test separately, and be asked both to guess the emotion in each vignette, and to speculate on which emotion the patient will guess. | one time visit, through study completion of 3 years |
| Geriatric Depression Scale (GDS) and differences between AD, PD, and FTLD | Assesses mood and depression in geriatric patients | one time visit, through study completion of 3 years |
| Neuroimaging and differences between AD, PD, and FTLD | Functional connectivity of networks associated with social cognition and personality | one time visit, through study completion of 3 years |
| D024801 |
| Tauopathies |
| D019636 | Neurodegenerative Diseases |
| D019965 | Neurocognitive Disorders |
| D001523 | Mental Disorders |
| D020734 | Parkinsonian Disorders |
| D001480 | Basal Ganglia Diseases |
| D009069 | Movement Disorders |
| D000080874 | Synucleinopathies |
| D057177 | TDP-43 Proteinopathies |
| D057165 | Proteostasis Deficiencies |
| D008659 | Metabolic Diseases |
| D009750 | Nutritional and Metabolic Diseases |