Adapted Physical Activity for Breast Cancer HER2 Positive Patient

Feasibility Study of an Adapted Physical Activity (APA) for Breast Cancer Patients Treated by Neoadjuvant Chemotherapy and Targeted Therapy Against HER2

The purpose of this study is to assess the feasibility of a home-based adapted physical activity during neoadjuvant chemotherapy for HER2+ breast cancer.

After the assessment of their physical fitness, a home-based adapted physical activity program composed by aerobic and muscle strengthening exercises will be delivered to each patient. The aim of the intervention is to reach international recommendation in a progressive way during neoadjuvant chemotherapy.

Inclusion Criteria:

• Women > 18 years old
• Patient with HER2 (Human Epidermal growth factor Receptor 2) positive breast cancer histologically proven, eligible for neoadjuvant chemotherapy and targeted therapy against HER-2
• Affiliation to the French social security scheme
• Patient who signed the participation consent before entering the trial
• Medical fitness certificate for sport

Exclusion Criteria:

• Diagnosis of a second malignancy in the past 5 years, with the exception of a basal cell skin cancer
• Metastatic cancer
• Karnofsky index ≤ 90%
• Men
• Pregnant women
• Significant psychiatric or neurological abnormality
• Patient deprived of liberty by a court or administrative
• Contraindication for physical activity
• Patient unable to complete questionnaires (language barrier)
• Participation in a clinical trial with the same objective