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Glutamate is known to be a mediator for apoptosis after brain hypoxia e.g. due to cardiac arrest. This pilot trial evaluates the possibility of elimination of Glutamate by CRRT after cardiac arrest.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRRT after cardiac arrest | Active Comparator | Continuous renal replacement therapy (CRRT) after cardiac arrest for 72 hours for elimination of Glutamate. Repetitive testing of blood Glutamate levels. |
|
| control | No Intervention | Repetitive testing of blood Glutamate levels without CRRT |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Continuous renal replacement therapy | Procedure |
|
| Measure | Description | Time Frame |
|---|---|---|
| Glutamate blood concentration in intervention arm over the time | Reduction of blood Glutamate concentration by renal replacement therapy | 72 hours |
| Measure | Description | Time Frame |
|---|---|---|
| number of participants with abnormal outcome parameters | up to 14 days |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Christian Storm, MD | Charite University, Berlin, Germany | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Charité-Universitätsmedizin Berlin | Berlin | 13353 | Germany |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 31557520 | Derived | Nee J, Jorres A, Krannich A, Leithner C, Schroeder T, Munk AL, Enghard P, Moore C, Steppan S, Storm C. Elimination of glutamate using CRRT for 72 h in patients with post-cardiac arrest syndrome: A randomized clinical pilot trial. Resuscitation. 2019 Nov;144:54-59. doi: 10.1016/j.resuscitation.2019.09.020. Epub 2019 Sep 23. |
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| ID | Term |
|---|---|
| D000079664 | Continuous Renal Replacement Therapy |
| ID | Term |
|---|---|
| D017582 | Renal Replacement Therapy |
| D013812 | Therapeutics |
| D005112 | Extracorporeal Circulation |
| D013514 | Surgical Procedures, Operative |
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