In Multiple Sclerosis the multiplicity of physical and psychological dysfunctions have been shown to exhibit a number of life-altering problems such as fatigue, limb weakness, alteration of upper extremity fine motor coordination, loss of sensation, spasticity. These problems affect performance of many daily living activities (ADL) such as dressing, bathing, self-care, and writing, thus reducing functional independence and self-rated quality of life.

Twenty people with Multiple Sclerosis will receive neurorehabilitation treatment comprising a combination of aerobic training and upper limb task-oriented training.

The aim of this pilot crossover study is to evaluate the effects of neurorehabilitation on upper limb performance and on fatigue in People with Multiple Sclerosis.

Inclusion Criteria:

• Diagnosis of Multiple Sclerosis
• no relapses in the last three months
• Expanded Disability Status Scale (EDSS) ≤ 8;

Exclusion Criteria:

• subjects with relapses
• worsening of the pathology in the last three months
• subjects with cognitive and psychiatric disturbances
• subjects with cardiovascular disease