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| Name | Class |
|---|---|
| University of Paris 5 - Rene Descartes | OTHER |
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The purpose of this study is determine the involvement of motor system in the memory of manipulable objects. The idea is to stimulate the ventral premotor cortex with transcranial magnetic stimulation to see whether this stimulation will affect memory of manipulable objects.
Embodied cognition claims that representations shares processing resources with sensorimotor systems. More specifically, it has been proposed that language comprehension relies on internal simulation of the meaning. For instance, numerous studies have shown that the processing of action-related concepts involve a motor activation similar to when the action is actually performed. However, even if those studies show clearly that action-related concepts involve a motor activation, such activations may be incidental to the activation of their representations, rather than part of it. Another way to show that this motor component takes part in the representation of manipulable objetcs is to investigate whether an impairment of motor system would impair the memory of manipulable object. In this study, investigators will use Transcranial Magnetic Stimulation (TMS) to stimulate ventral premotor cortex (PMv) to see whether this stimulation will affect memory of manipulable objects, but not memory of nonmanipulable objects. For this purpose, three TMS conditions will be assessed: cTBS to inhibit the motor cortex, iTBS to excite the motor cortex, and a SHAM condition as control.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group iTBS-cTBS-SHAM | Other | PMv stimulation (iTBS) at session 2, PMv inhibition (cTBS) at session 3, and control (SHAM) at session 4 |
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| Group iTBS-SHAM-cTBS | Other | PMv stimulation (iTBS) at session 2, control (SHAM) at session 3, and PMv inhibition (cTBS) at session 4 |
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| Group cTBS-iTBS-SHAM | Other | PMv inhibition (cTBS) at session 2, PMv stimulation (iTBS) at session 3, and control (SHAM) at session 4 |
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| Group cTBS-SHAM-iTBS | Other | PMv inhibition (cTBS) at session 2, control (SHAM) at session 3, and PMv stimulation (iTBS) at session 4 |
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| Group SHAM-iTBS-cTBS | Other | control (SHAM) at session 2, PMv stimulation (iTBS) at session 3, and PMv inhibition (cTBS) at session 4 |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| PMv stimulation (iTBS) | Other | PMv stimulation (iTBS) |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of objects affordants and of objects not - affordants reminded | Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is in PMv or control | 1 week |
| Number of objects affordants and of objects not - affordants reminded | Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is in PMv or control | 2 weeks |
| Number of objects affordants and of objects not - affordants reminded | Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is in PMv or control | 3 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Number of object reminded | Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is excitation or control | 1 week |
| Number of object reminded |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Benoit CREPON, MD | Contact | 00 33 1 45 65 87 70 | b.crepon@ch-sainte-anne.fr | |
| Marie GODARD | Contact | 00 33 1 45 65 77 28 | marie.godard@aphp.fr |
| Name | Affiliation | Role |
|---|---|---|
| Pascale PIOLINO | University of Paris 5 - Rene Descartes | Study Director |
| Benoit CREPON, MD | CHSA | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Centre de Recherche Clinique (CRC) - CHSA | Recruiting | Paris | 75014 | France |
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| ID | Term |
|---|---|
| C005703 | salicylhydroxamic acid |
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| Group SHAM-cTBS-iTBS | Other | control (SHAM) at session 2, PMv inhibition (cTBS) at session 3, and PMv stimulation (iTBS) at session 4 |
|
| PMv inhibition (cTBS) | Other | PMv inhibition (cTBS) |
|
| Control (SHAM) | Other | Control (SHAM) |
|
Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is excitation or control
| 2 weeks |
| Number of object reminded | Measure of the number of objects affordants and of objects not - affordants reminded according to if the stimulation is excitation or control | 3 weeks |