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CRICS financial report for the first budget year of the study
Vietnam Cryptococcal Retention in Care Study (CRICS) federal financial report for the first budget year of the study
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Assigned Interventions Antifungals Patients with symptoms | Other | Patients with symptoms of CNS disease will be treated according to Vietnam national guidelines for HIV/AIDS management. For CrAg-positive patients, the initial dosage of fluconazole will be 900 mg taken each day for 2 weeks. This will be followed by fluconazole 450 mg orally each day for 8 weeks. Finally, maintenance treatment with fluconazole 200mg orally each (2 tablets of 100 mg procured especially for the study) day will continue until CD4 >200 cells/µL for at least 6 months. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vietnam Cryptococcal Retention in Care Study (CRICS) | Other | Drug: Fluconazole HIV-infected patients with CD4 ≤100 cells/μL who present for HIV care at outpatient clinics (OPCs) in Vietnam where CrAg screening is offered will be recruited into the study. Study participants will be screened for cryptococcal antigen using the Lateral Flow Assay (LFA). Those who are CrAg-positive, but have no features of central nervous system (CNS) disease, will be treated with high-dose fluconazole. Other Names: • Fluconazole |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients who have advanced HIV disease (CD4 <100) | 12 months | |
| Prevalence of CrAg-positivity among HIV patients with advanced disease | 12 months | |
| The proportion of patients who have no new opportunistic infections at 12 months | 12 months | |
| Mortality rate among HIV patients with advanced disease | 12 months |
| Measure | Description | Time Frame |
|---|---|---|
| The proportion of patients with advanced HIV disease who retain in HIV care at 6 months and 12 months | Up to 12 months |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Nguyen V Kinh, Dr | NHTD | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| National hospital for tropical diseases | Ham Zong | Vietnam |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34446679 | Derived | Dat VQ, Lyss S, Dung NTH, Hung LM, Pals SL, Anh HTV, Kinh NV, Bateganya M. Prevalence of Advanced HIV Disease, Cryptococcal Antigenemia, and Suboptimal Clinical Outcomes Among Those Enrolled in Care in Vietnam. J Acquir Immune Defic Syndr. 2021 Dec 15;88(5):487-496. doi: 10.1097/QAI.0000000000002786. |
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| ID | Term |
|---|---|
| D016919 | Meningitis, Cryptococcal |
| D000163 | Acquired Immunodeficiency Syndrome |
| ID | Term |
|---|---|
| D016921 | Meningitis, Fungal |
| D020314 | Central Nervous System Fungal Infections |
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
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|
| D007239 | Infections |
| D003453 | Cryptococcosis |
| D002494 | Central Nervous System Infections |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D008581 | Meningitis |
| D000090862 | Neuroinflammatory Diseases |
| D015658 | HIV Infections |
| D000086982 | Blood-Borne Infections |
| D003141 | Communicable Diseases |
| D015229 | Sexually Transmitted Diseases, Viral |
| D012749 | Sexually Transmitted Diseases |
| D016180 | Lentivirus Infections |
| D012192 | Retroviridae Infections |
| D012327 | RNA Virus Infections |
| D014777 | Virus Diseases |
| D012897 | Slow Virus Diseases |
| D000091662 | Genital Diseases |
| D000091642 | Urogenital Diseases |
| D007153 | Immunologic Deficiency Syndromes |
| D007154 | Immune System Diseases |